Comparison of the Therapeutic Effects of Vaginal Repair With Leuprorelin and Vaginal Repair in the Treatment of Cesarean Section Scar Defect

Launched by XINHUA HOSPITAL, SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE · Jan 11, 2022

Keywords

ClinConnect Summary

This clinical trial is studying two different treatment methods for women who have a specific problem called Cesarean Section Scar Defect (CSD) along with adenomyosis, a condition where the tissue that normally lines the uterus grows into the uterine wall. The trial compares the effects of a vaginal repair surgery combined with a medication called Leuprorelin, which is used to delay menstrual periods, to vaginal repair surgery without this medication. The goal is to see if postponing the period can improve the recovery from CSD.

To participate in this trial, women should be between 18 and 62 years old and must have a clear diagnosis of CSD along with adenomyosis. They should also experience heavy menstrual bleeding and have certain medical criteria, like having a thin muscular layer of the uterus. Participants will need to sign a consent form and will be monitored throughout the study. Important to note, those with serious health issues, pregnancy, or specific allergies will not be eligible to join.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • 1. Clearly diagnosed with CSD complicated with adenomyosis
• • 2. Experiencing clinical features of abnormal uterine bleeding, prolonged menstrual flow (the duration of menstruation is more than 10 days).
• • 3. The thickness of the remaining muscular layer of CSD was less than 3 mm.
• • 4. Normal range of blood sugar and insulin
• • 5. No serious medical problems (important viscera function in the normal range).
• • 6. uterine fibroids no more than 5cm
• • 7. Sign the informed consent.
• Exclusion Criteria:
• • 1. Indefinite diagnosis.
• • 2. Malignant tumors.
• • 3. With severe medical problems (severe liver disease, kidney disease, respiratory diseases, heart disease or uncontrolled diabetes, epilepsy, etc., dysfunction of important organs).
• • 4. Pregnant.
• • 5. Mental diseases.
• • 6. Allergy to the any ingredients of Leuprorelin
• • 7. Unwilling to comply with the research plan.