Adjuvant Effect of Physical Exercise on Immune Response to COVID-19 Vaccination and Interactions With Stress

Launched by IOWA STATE UNIVERSITY · Jan 24, 2022

Keywords

ClinConnect Summary

This clinical trial is studying whether doing light to moderate exercise shortly after receiving the COVID-19 vaccine can improve the body's immune response to the vaccine. Researchers want to see if a single session of exercise, like a brisk walk or jog, performed within 30 minutes of vaccination can help increase the levels of antibodies and T cells that fight infections. They’ll also explore how stress and other psychological factors might affect how well the vaccine works. Participants will either take part in a 90-minute exercise session after getting vaccinated or continue their usual daily routine without exercise.

To join the study, participants need to be between 18 and 64 years old, regularly exercise at least twice a week, and be able to safely perform the exercise required in the trial. They should also be planning to receive the mRNA COVID-19 vaccine. During the study, participants will provide blood samples at different times to measure their immune response, and they will fill out surveys about their physical activity and stress levels. Participants can expect to be monitored for side effects for three days after vaccination and will be involved over the course of a year to see how their immune response changes.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Able to donate a small amount of blood,
• • Planning to receive an initial mRNA Severe Acute Respiratory Distress Syndrome Coronavirus 2 vaccine,
• • Between 18-64 years of age,
• • Regularly participate in some form of exercise two or more times per week, including at least one session equal to or greater than 50 minutes exercise sessions or walk three or more times per week with at least one session equal to or greater than 50 minutes.
• • Can safely perform 90 minutes of light to moderate intensity exercise (walk, walk/jog, or jog) based on American College of Sports Medicine exercise participation guidelines
• Exclusion Criteria:
• • Currently pregnant
• • Weigh less than 110 pounds.
• • Presence of any conditions that could significantly impact the ability to exercise safely, or unable to receive the mRNA COVID-19 vaccine
• • Taking medication that significantly impact immune response or the presence of an immune disorder.