Effectiveness of iPRF Injections in Temporomandibular Joints Degeneration Management
Launched by WROCLAW MEDICAL UNIVERSITY · Jan 17, 2022
Trial Information
Current as of June 27, 2025
Enrolling by invitation
Keywords
ClinConnect Summary
Background: The term temporomandibular disorders is used to describe a wide spectrum of functional modifications and pathological conditions involving the temporomandibular joints, masticatory muscles and other surrounding structures. Temporomandibular disorders are the second most common cause of pain symptoms in the craniofacial area. It is estimated that they may affect up to 56% of the adult Polish population. One of the most common forms of temporomandibular disorders are intra-articular abnormalities. They can lead to degeneration within the articular surfaces and articular disc of th...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • age between 18 and 80 years old
- • mild to moderate degenerative temporomandibular joint disease based on DC/TMD protocol and MRI/CT
- • agreement to take part in the study
- Exclusion Criteria:
- • severe hematologic and/or neurological disorder
- • rheumatoid arthritis
- • septic arthritis
- • polymyalgia rheumatica
- • gout
- • Paget's disease
- • osteonecrosis
- • connective tissue disease
- • malignant disease
- • vasculitis
- • any previous temporomandibular joint (TMJ) invasive treatment
- • any current temporomandibular joint (TMJ) conservative or invasive treatment
- • patients who had used oral, parenteral or intra-articular corticosteroids in the 3 months prior to the first injection
- • previous or current radiotherapy of head and neck
- • pregnancy or lactation
- • presence of severe mental disorders
- • drug and/or alcohol addiction
- • presence of local contraindications for injection therapy
- • patients with needle phobia
- • presence of hypersensitivity to substances to be used in the study
About Wroclaw Medical University
Wrocław Medical University is a prestigious academic institution located in Wrocław, Poland, renowned for its commitment to advancing medical research and education. As a clinical trial sponsor, the university leverages its extensive expertise in healthcare and biomedical sciences to facilitate innovative research initiatives aimed at improving patient outcomes. With a strong emphasis on ethical practices and regulatory compliance, Wrocław Medical University collaborates with a diverse network of healthcare professionals and researchers to conduct rigorous clinical trials that contribute to the development of new therapies and enhance the understanding of various medical conditions. Its dedication to scientific excellence and patient safety positions the university as a key player in the global clinical research landscape.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Wrocław, , Poland
Patients applied
Trial Officials
Mieszko Wieckiewicz, Prof.
Study Chair
Wroclaw Medical University
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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