Sex Disparities in Hypoxic Vasodilation and Impact of Obesity

Launched by UNIVERSITY OF MISSOURI-COLUMBIA · Jan 21, 2022

Keywords

ClinConnect Summary

This clinical trial is studying how men and women respond differently to low oxygen levels in the body, particularly in relation to obesity and the nervous system. Researchers want to understand the reasons behind these differences, which could help improve treatments for people with obesity. The trial is currently looking for participants aged 65 to 74 who have a body mass index (BMI) over 18. However, individuals with certain health issues, such as pregnancy, diagnosed sleep apnea, or significant heart or kidney problems, among others, are not eligible to participate.

If you qualify and decide to join the trial, you can expect to be part of important research that could shed light on how obesity affects blood flow and oxygen delivery in different sexes. This study aims to gather valuable information that could lead to better health outcomes for both men and women with obesity. Your participation could make a difference in understanding these important health issues!

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • BMI \>18 kg/m2
• Exclusion Criteria:
• • Pregnancy, breastfeeding
• • Diagnosed sleep apnea or AHI \>10 events/hr
• • Current smoking/Nicotine use
• • Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy
• • Nerve/neurologic disease
• • Cardiovascular, hepatic, renal, respiratory disease
• • Blood pressure ≥140/90 mmHg
• • Diabetes, Polycystic ovarian syndrome
• • Communication barriers
• • Prescription medications, Sensitivity to lidocaine