Evaluating the Impact of Computer-assisted X-ray Diagnosis and Other Triage Tools to Optimise Xpert Orientated Community-based Active Case Finding for TB and COVID-19

Launched by UNIVERSITY OF CAPE TOWN · Feb 1, 2022

Keywords

ClinConnect Summary

This clinical trial is studying new ways to improve the detection of tuberculosis (TB) and COVID-19 in communities, especially in African countries where these diseases are common. Researchers want to see how effective computer-assisted X-ray technology can be in identifying potential TB cases, as it may work just as well as experienced doctors. They are also exploring other innovative tests, like urine and blood tests, to help find cases of TB and COVID-19. This is important because many people with these conditions go undiagnosed, which makes it harder to control their spread in the community.

To participate in this trial, individuals must be 18 years or older and be willing to undergo various tests, including blood and urine samples. Both HIV-positive and HIV-negative participants can join. However, those who have recently completed TB treatment, are currently being treated for TB, or are unable to provide informed consent due to health reasons cannot participate. Participants can expect to be involved in community screenings and may receive updates about their health as the study progresses. This trial aims to gather important information about how to better detect and manage TB and COVID-19 in the community.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Participants willing to complete community-based symptom screening, finger-prick and venepuncture blood sampling, urine testing, and/or undergo TB and/or COVID-19 diagnostic testing.
• • Provision of informed consent.
• • Participant 18 years or above.
• • HIV-positive or negative participants will be included.
• Exclusion Criteria:
• • Inability to provide informed consent (e.g., mentally impaired).
• • Participants who have completed TB treatment in the last two months, or who have self-presented to their local TB clinic and are currently being worked up for suspected TB.
• • Participants already diagnosed with active TB on treatment.
• • Participants unable to commit to at least a two-month follow-up.
• • Female participants who are pregnant or who refuse a urine pregnancy test.
• • Participants in the community who cannot access healthcare due to severe ill health or lack of access to the local clinic.