Single Dose Amikacin for Uncomplicated Cystitis in the ED: A Feasibility Study

Launched by ANTONIOS LIKOUREZOS · Jan 27, 2022

Keywords

ClinConnect Summary

This clinical trial is exploring whether a single dose of amikacin, an antibiotic, can effectively treat women with uncomplicated urinary tract infections (UTIs) who visit the emergency department. Instead of having to take antibiotics for several days after getting a prescription, participants in this study will receive one shot of amikacin, either in the arm or through an IV. This method aims to simplify treatment and help patients feel better faster. While previous studies have shown that this approach is safe and well-tolerated, some patients may choose not to participate if they are uncomfortable with getting a shot or having phone conversations with a research assistant over the next month.

To be eligible for the study, participants must be female, at least 14 years old, and diagnosed with an uncomplicated UTI. They should have specific symptoms and test results that indicate a typical urinary infection. However, pregnant women, those with certain medical conditions affecting the urinary tract, or those recently treated with antibiotics are not eligible. If you decide to join the trial, you can expect to receive the antibiotic shot during your emergency visit and will need to check in with a research team by phone at three different times over the following month. This study is currently looking for participants, so if you meet the criteria and are interested, please consider discussing it with your healthcare provider.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • female emergency medicine patients
• • ≥14 years of age
• • uncomplicated urinary tract infection
• • a primary urinary complaint and nitrite-positive urine.
• Exclusion Criteria:
• • pregnancy
• • abnormal genitourinary tract
• • recent urinary tract instrumentation
• • immunosuppression
• • CrCl \< 25 mL/min
• • evidence of pyelonephritis or sepsis
• • any antibiotic treatment within 30 days
• • not available for phone follow-up in 3, 7, and 30 days
• • requires admission to the hospital
• • abnormal mental status.