Intranasal Ketamine Versus Subcutaneous Ketamine for Treatment of Post-traumatic Acute Pain in the Emergency Department ( INVESCK )

Launched by UNIVERSITY OF MONASTIR · Feb 5, 2022

Keywords

ClinConnect Summary

The INVESCK trial is studying two different ways to manage severe pain from limb injuries in patients visiting the emergency department (ED). Researchers want to compare the effectiveness of intranasal ketamine, which is a medication given through the nose, to subcutaneous ketamine, which is injected just under the skin. Both methods aim to provide quick and effective pain relief for patients suffering from acute trauma pain.

To be eligible for this trial, participants should be between 18 and 75 years old and must have experienced recent limb trauma with a pain level of 5 or higher on a scale from 0 to 10. However, certain individuals cannot join, including those who are pregnant, have severe health issues, or have specific medical histories like head injuries or mental health conditions. If you join the trial, you can expect to receive one of the treatments and be monitored by healthcare professionals to see how well it works for your pain. Your safety and comfort will be prioritized throughout the study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • • Patients who presented to the ED with acute limb trauma pain with a visual analgesic scale (VAS) of 5 or more on a standard 11 point (0-10).
• • Pain was considered traumatic if it is reported as appearing immediately after the trauma and no anterior pain was described in the same limb.
• Exclusion Criteria:
• • Pregnancy/Breastfeeding
• • altered mental status (GCS\<15)
• • Allergy to ketamine or morphine
• • Weight less than 40 kg or greater than 100kg
• • Unstable vital signs (systolic blood pressure \<90 or \> 180mmHg, pulse rate\<50 or \>150bpm, and respiration rate \<10 or \>30 breath/min)
• • Medical history of acute head or eye injury
• • Medical history of seizure
• • Medical history of intracranial hypertension,
• • Medical history of chronic pain,
• • Medical history of severe renal or hepatic insufficiency.
• • Medical history of glaucoma
• • Alcohol or drug abuse
• • Psychiatric illness,
• • Recent (4 hours before) analgesic agent use.