Prevalence of Endolymphatic Hydrops With a Hitory of Congenital Cytomegalovirus Infection

Launched by FONDATION OPHTALMOLOGIQUE ADOLPHE DE ROTHSCHILD · Feb 7, 2022

Keywords

ClinConnect Summary

This clinical trial is studying a condition called endolymphatic hydrops, which is related to problems in the inner ear that can affect hearing and balance. The researchers want to understand how common this condition is in people who have a history of congenital cytomegalovirus (CMV) infection, a virus that can affect babies before they are born. They are currently looking for participants who are over 6 months old and have been diagnosed with congenital CMV infection, along with experiencing issues with hearing or balance.

Eligible participants will need to provide consent to join the study, and if they are minors, both parents must agree. Those who join the trial may undergo tests that include MRI scans to help assess their condition. It’s important to note that certain individuals, such as pregnant or breastfeeding women, or those with specific medical conditions, cannot participate. This study aims to improve our understanding of how congenital CMV infection may relate to ear problems, which could ultimately help in managing these patients better.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patient over 6 months old
• • With a history of confirmed congenital CMV infection
• • Suffering from symptomatic cochleo-vestibular dysfunction (average hearing threshold\> 20dB in at least one ear and / or abnormal functioning of one or more sectors at the vestibular level)
• • For adult patients, having received informed information about the study and having signed a consent to participate in the study
• • For minor patients written consent of the two holders of the exercise of parental authority
• • Affiliate or beneficiary of a social security scheme
• Exclusion Criteria:
• • Patient benefiting from a legal protection measure
• • Pregnant or breastfeeding woman
• • Contraindication to MRI (implanted electrical device, metallic foreign body, claustrophobia)
• • Patient with a proven allergy to gadolinium
• • Injection of gadolinium in the previous 7 days
• • Known impairment of renal function ((estimated GFR \<60 mL / min / 1.73 m²)