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Search / Trial NCT05236959

Mindfulness-Based Cognitive Therapy for Depressed IAPT Non-Responders

Launched by SUSSEX PARTNERSHIP NHS FOUNDATION TRUST · Feb 2, 2022

Trial Information

Current as of July 21, 2025

Unknown status

Keywords

ClinConnect Summary

Major Depression represents a pressing challenge for health care. The disorder is not only highly prevalent but also shows many characteristics of a progressive disorder. If not treated sufficiently, it tends to become more recurrent and chronic over time.

In order to address this challenge, it is imperative to provide treatments that effectively reduce symptoms in those who are affected. In England and other parts of the United Kingdom, Increasing Access to Psychological Therapies (IAPT) services have been introduced with the aim of providing evidence-based psychological therapies in a ti...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria will be
  • 1. non-response to a minimal effective dose of high intensity treatment in IAPT (at least 12 sessions, in line with NICE draft guideline suggestions) defined in line with the caseness threshold adopted by IAPT as a Patient Health Questionnaire-9 (PHQ-9) score of 10 or higher
  • 2. meeting criteria for a current episode of Major Depression according to DSM-5 as assessed through the Mini International Neuropsychiatric Interview for DSM-5
  • 3. age 18 or older
  • 4. access to a working internet connection to participate in videoconferencing assessments and interventions
  • Potential participants will be excluded if
  • 1. based on the judgment of their IAPT therapist they are eligible for, would be seen by, and their needs would be best met by secondary care specialist services
  • 2. they present with a level of risk to self or others that cannot be safely managed in a primary care service context (i.e. active suicidal plans), a history of psychosis or psychotic symptoms, a current episode of mania, alcohol or substance abuse or dependence within the past 3 months, current post-traumatic stress disorder, obsessive-compulsive disorder or eating disorder.
  • 3. they suffer from any other significant disease or disorder that may either put the participant at risk because of participation in the trial, or may influence the result of the trial, or the participant's ability to participate in the trial
  • 4. if they have an insufficient ability to understand or read English.
  • Patients who are currently taking antidepressant medication will be allowed into the trial and medication use will be documented for statistical analysis.

About Sussex Partnership Nhs Foundation Trust

Sussex Partnership NHS Foundation Trust is a leading provider of mental health and learning disabilities services in Sussex, England. Committed to delivering high-quality care and advancing clinical research, the Trust plays a pivotal role in enhancing mental health outcomes through innovative trials and evidence-based practices. With a multidisciplinary team of healthcare professionals, Sussex Partnership prioritizes patient-centered approaches and actively collaborates with academic institutions and other stakeholders to drive research initiatives that inform and transform mental health services. Their dedication to clinical excellence and research integrity positions them as a key player in the advancement of mental health care.

Locations

London, , United Kingdom

Brighton, Sussex, United Kingdom

Exeter, Devon, United Kingdom

Exeter, , United Kingdom

Patients applied

0 patients applied

Trial Officials

Thorsten Barnhofer, PhD

Principal Investigator

University of Surrey

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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