Non-surgical vs. Surgical Therapy for Periodontal Furcations
Launched by KING'S COLLEGE LONDON · Feb 2, 2022
Trial Information
Current as of June 26, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is investigating the best treatment options for patients with advanced gum disease, specifically focusing on a condition called furcation involvement, which occurs when the bone loss around the roots of molar teeth makes it difficult to treat them effectively. The study is looking at whether non-surgical methods or surgical procedures work better for improving the health of these teeth and preventing tooth loss. It’s important because many people with severe gum disease experience this issue, and there hasn’t been a lot of research on the best ways to treat it.
To participate in the trial, individuals should have at least 12 teeth and be diagnosed with severe periodontitis (a serious form of gum disease). They need to have at least one molar tooth with significant bone loss and specific conditions that make it hard to keep clean. Participants can expect to receive either non-surgical or surgical treatment, depending on what the trial is studying. If you or someone you know has severe gum disease and meets these criteria, this trial could provide helpful insights into managing furcation involvement effectively.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Minimum of 12 teeth present
- • Diagnosis of Severe Periodontitis stage III or IV
- • At least one maxillary/ mandibular molar with: i) degree III horizontal furcation involvement (at least between 2 roots for maxillary molars) , ii) class B vertical furcation involvement (bone loss up to the middle third of root cones), iii) residual probing pocket depths \> 5 mm in furcation area, iv) maximum mobility degree Iand v) not already accessible for self-performed oral hygiene
- • Received a course of non-surgical periodontal therapy within the past six months
- Exclusion Criteria:
- Patient:
- • Full mouth plaque score \> 30%
- • A course of antibiotics within the past 3 months
- • Pregnant/lactating women
- • Relevant medical history as evaluated by the examining clinician which may have the potential to affect periodontal surgical treatment
- • Individuals on long-standing (2 or above years) supportive periodontal therapy (SPT) management plans
- Molar affected by FI:
- • Ongoing endodontic pathology affecting the furcation involved molar, as judged by the examining clinician
- • Previous periodontal surgical treatment to the furcation affected molar within the previous 5 years
- • Endodontically treated molar tooth without a full coverage restoration
- • 'Unrestorable' molar tooth (lacking adequate tooth structure to provide a restoration) as deemed by the examining clinician.
- • Molar tooth acting as a bridge abutment
- • The presence of occlusal dysfunction as assessed by the examining clinician
About King's College London
King's College London is a prominent research institution renowned for its commitment to advancing healthcare through innovative clinical trials. With a strong emphasis on interdisciplinary collaboration, the college leverages its extensive expertise in medicine, neuroscience, and public health to conduct rigorous studies aimed at improving patient outcomes. As a sponsor of clinical trials, King's College London prioritizes ethical standards, participant safety, and scientific integrity, fostering an environment that encourages groundbreaking research and the translation of findings into clinical practice. Through its state-of-the-art facilities and a diverse network of researchers, the institution strives to address critical health challenges and contribute to the global body of medical knowledge.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
London, , United Kingdom
Patients applied
Trial Officials
Luigi Nibali
Study Chair
King's College London
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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