Childhood Traumas in Obese Women: Association With Deregulation of the Glucocorticoid Axis and Inflammatory State.

Launched by UNIVERSITY HOSPITAL, LIMOGES · Feb 2, 2022

Keywords

ClinConnect Summary

This clinical trial is looking at how childhood trauma might affect the health of obese women. Researchers want to find out if women who experienced trauma in their childhoods have different levels of a hormone called cortisol when they wake up compared to those who did not have such experiences. Cortisol is important because it helps regulate stress and inflammation in the body, which can be linked to obesity.

To participate in this study, women must be at least 18 years old and have a body mass index (BMI) of 30 or higher, which means they are considered obese. However, there are certain conditions that would exclude someone from joining, such as recent pregnancy, certain heart or liver diseases, or if they are currently taking specific medications. Participants will provide saliva samples to measure cortisol levels and will complete a questionnaire about their childhood experiences. This study aims to better understand the connections between past trauma, stress responses, and obesity, which could help improve treatments in the future.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • ≥18 years female BMI≥30kg/m2
• Exclusion Criteria:
• • 1. History of bariatric surgery
• 2. Any condition or pathology that may influence the corticotropic axis or that may modify the excretion or dosage of cortisol:
• • pregnancy, breastfeeding
• • hepatocellular insufficiency,
• • severe heart failure,
• • mild/moderate acute heart failure,
• • any psychological disorder not stabilised for at least one year
• • alcohol or drug dependence, not weaned for at least one year
• • neoplasm under treatment
• • 3. Current infectious disease or a history of autoimmune disease (except autoimmune hypothyroidism), inflammatory disease and/or neurodegenerative disease
• • 4. Presence of an adrenal adenoma or any known or suspected clinical adrenal or corticotropic disorder
• • 5. Subjects with a positive diagnosis of hypercorticism or suspected hypercorticism will also be excluded: 8-hour plasma cortisol after Dexamethasone suppression test (DST) (1 mg dexamethasone taken orally at midnight the previous day) greater than 1.8 microg/100 ml (50 nmol/l)
• • 6. antidepressant and neuroleptic treatment, benzodiazepine treatment
• • 7. treatment(s) likely to modify the exploration of the corticotropic axis: systemic or local corticosteroid therapy or glucocorticoid infiltration for less than 6 months
• • 8. current use of anti-inflammatory drugs or antibiotics
• • 9. Shift worker