"SCRIBBLE" Spinal Cord Injury Blood Biomarker Longitudinal Evaluation

Launched by UNIVERSITY OF BRITISH COLUMBIA · Feb 7, 2022

Keywords

ClinConnect Summary

The SCRIBBLE trial is a research study aimed at understanding how certain blood markers can help doctors determine the severity of spinal cord injuries and predict how well patients might recover. This study focuses on patients who have experienced traumatic spinal cord injuries, either complete or incomplete, and will also involve patients with spinal fractures that do not affect the spinal cord. By collecting blood samples soon after the injury, researchers hope to find ways to better assess these injuries and support future studies.

To participate in this study, individuals must be at least 19 years old and have suffered a blunt spinal cord injury or a spinal fracture without damage to the spinal cord. Participants will need to have a blood sample taken within 24 hours of their injury and must be willing to provide consent for the study. If you or a loved one qualifies, joining this trial could contribute to valuable research that may improve care for future spinal cord injury patients.

Gender

ALL

Eligibility criteria

• • Inclusion Criteria
• SCI Participants. Patients who suffer a traumatic spinal cord injury who meet the following inclusion criteria are eligible for admission into the study as "SCI participants":
• • Male or Female ≥ 19 years of age
• • Blunt (non-penetrating) traumatic spinal cord injury
• • Baseline neurologic impairment deemed "complete"(AIS A) or "incomplete" (AIS B, C, D)
• • Bony spinal level involvement between C0 and L1 inclusive
• • Ability to have initial blood sample drawn within 24 hours of injury
• • Have either an arterial line, central line, or intravenous line for collecting blood samples
• • Able and willing to provide informed consent
• Non-SCI Spine Trauma Control Participants. Patients who suffer a fracture or dislocation of their spinal column without neurologic injury who meet the following inclusion criteria are eligible for admission into the study as "Non-SCI Spine Trauma Control Participants":
• • Male or Female ≥ 19 years of age
• • Traumatic spinal fracture between C0 and L1 without spinal cord injury
• • Collection of initial blood sample within 24 hours of injury
• • Have either an arterial line, central line, or intravenous line for collecting blood samples
• • Able and willing to provide informed consent
• • Exclusion Criteria
• Patients who fulfill any of the following criteria are not eligible for admission into the study:
• • Penetrating spinal cord injury (e.g. gunshot, stab)
• • Spinal cord injury with sensory deficit only (i.e. no motor deficit)
• • Spinal injury below L1
• • Isolated radiculopathy without fracture
• • Isolated cauda equina injury
• • Pre-existing thromboembolic disease or coagulopathy (disorders related to blood clotting), such as haemophilia or von Willebrand's disease
• • Have any other medical condition that in the investigator's opinion would render the study procedures dangerous or impair their ability to receive treatment