Trauma and Critical Care Exposure Examined With PET (TRAPETS)

Launched by KAROLINSKA UNIVERSITY HOSPITAL · Feb 16, 2022

Keywords

ClinConnect Summary

The TRAPETS trial is studying how trauma and serious illness affect the brain and thinking abilities. Researchers want to learn more about the impact of being in an intensive care unit (ICU) after a traumatic injury. To do this, they will closely examine twenty trauma patients over a year using special imaging tests, brain activity monitoring, and cognitive tests. These examinations will take place within three weeks of the injury, then again after three months, and finally after twelve months.

To participate in this study, patients must be between 20 and 60 years old and have experienced a significant injury. They should also be able to provide informed consent, meaning they understand the study and agree to take part. Those with certain pre-existing conditions, such as severe mental health disorders or a history of serious brain injuries, cannot join the trial. Participants can expect regular check-ups and tests that will help researchers understand how trauma affects both the brain and the body over time.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patients 20-60 years of age.
• • 2. Trauma with an ISS score of ≥15
• • 3. Informed consent
• Exclusion Criteria:
• • 1. Patient´s refusal to participate in the trial
• • 2. Any traumatic brain or spinal injury prior to admission
• • 3. Disabling neuropsychiatric disorder (dementia-diagnosis, Mb Alzheimer, Mb Parkinson, schizophrenia or severe mental depression prior to ICU admission)
• • 4. Any preadmission history of stroke with neurological sequelae
• • 5. Co-morbidities prior to ICU admission such as severe cardiac, hepatic, hematological or renal impairment
• • 6. Terminal phase of chronic disease or malignancy
• • 7. High-dose steroid treatment before ICU admission or during ICU care
• • 8. Presumed uncooperativeness or legal incapacity