Neoadjuvant Long-course Chemoradiation Plus PD-1 Blockade for Mid-low Locally Advanced Rectal Cancer

Launched by BEIJING FRIENDSHIP HOSPITAL · Feb 6, 2022

Keywords

ClinConnect Summary

This clinical trial is looking at a new treatment approach for patients with locally advanced rectal cancer, which is cancer located in the lower part of the intestine near the rectum. The study is testing whether combining standard treatments, like chemotherapy and radiation (known as chemoradiation), with a medication called Tislelizumab (which helps the immune system fight cancer) can improve outcomes for patients. Participants will be divided into three groups: one group will receive chemoradiation along with Tislelizumab, another group will receive chemoradiation followed by Tislelizumab, and the last group will receive chemoradiation only.

To be eligible for this trial, participants need to be between 18 and 75 years old and have been diagnosed with rectal cancer that hasn’t spread to other parts of the body. They should also be in reasonably good health overall, with no significant problems with their heart, lungs, or other major organs. Participants can expect to receive regular monitoring and support during the trial. It’s important for potential participants to know that they cannot have had any previous cancer treatments or significant health issues that could interfere with the study. This trial is currently recruiting, and all genders are welcome to participate.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • aged 18\~75
• • ECOG score 0\~2
• • biopsy diagnosed rectal adenocarcinoma, distal margin within 10cm to anal verge
• • no distant metastasis, staged II/III (T4b excluded) by MRI
• • maximum diameter of rectal cancer lesion≥10mm according to baseline CT or MRI (i.e. a "measurable lesion" as per RECIST 1.1 criteria)
• • willing and able to comply with study protocol
• • consent to the use of blood and tissue specimens for study
• • no history of previous anti-tumor treatment (e.g. radiation, chemo, immuno, bio, herbal, etc.)
• • no disorders/diseases of immune system (e.g. systemic lupus erythematosus, rheumatoid arthritis, systemic vasculitis, scleroderma, pemphigus, dermatomyositis, mixed connective tissue disease, autoimmune hemolytic anemia, hyperthyroidism/hypothyroidism, ulcerative colitis, autoimmune hemolytic anemia, HIV infection, etc.)
• • no significant dysfunction of major viscera (e.g. heart, lung, liver, kidney, etc.)
• • no jaundice or gastrointestinal obstruction
• • no acute/ongoing infection
• • no significant irregularities in blood routine test and biochemical test results, particular requirements include: neutrophils≥1.5×109/L, HGB≥80g/L, platelet≥100×109/L, serum creatinine≤1.5×ULN, total bilirubin≤1.5×ULN, ALT、AST≤2.5×ULN
• • no social or mental disorder
• • for women of child-bearing age, a negative result of serological pregnancy test is required, and effective contraception measures from inclusion till 60 days after the last dose of study drug is required
• Exclusion Criteria:
• • multiple cancers, or with concomitant malignant tumors besides rectal cancer
• • having received any anti-cancer treatment (surgery, drugs, etc.) in the past 5 years
• • history of recent major surgery
• • with condition that affects the absorption of capecitabine via gastrointestinal tract (e.g. inability to swallow, nausea, vomiting, chronic diarrhea, etc.)
• • with uncontrolled, severe, concomitant diseases of any sort
• • allergic to any of the ingredients under study
• • estimated survival ≤ 5 years due to any reason
• • preparing for or having previously received organ or bone marrow transplant
• • having received immunosuppressive or systemic hormone therapy for immunosuppressive purposes within 1 month prior to inclusion
• • for patients with history of disorder of central nervous system, investigator discretion is required as to whether the clinical severity prevents the signing of informed consent or affects the patient's oral medication compliance
• • with other conditions/issues that may affect the study results or cause the study treatment to be terminated halfway (e.g. alcoholism, drug abuse, etc.)
• • pregnant or lactating women, or women intending on conception during treatment period