The Expected Advantage of Administering Prophylactic Antibiotics Using Target- Concentration Controlled Infusion

Launched by ASAN MEDICAL CENTER · Feb 22, 2022

Keywords

ClinConnect Summary

This clinical trial is studying a new way to give antibiotics before surgery, specifically for patients undergoing colorectal surgery. The researchers want to see if using a method called target-concentration controlled infusion (TCI) can more effectively administer the antibiotic cefoxitin. This approach aims to provide a personalized dose based on individual factors like a person’s weight and kidney function, helping to ensure that the right amount of the drug is in the body to prevent infections after surgery.

To participate in this trial, you must be over 20 years old and scheduled for colon or rectal surgery where cefoxitin will be given as a preventive measure. However, you cannot join if you have an allergy to cefoxitin, have used it recently, or have certain kidney issues. If you take part in this study, you would receive cefoxitin through a special syringe pump that adjusts the dosage based on your individual needs. This could potentially lead to better outcomes and fewer infections after surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • over 20 years old
• • Patients who are scheduled to undergo colon or rectal surgery
• • Patients scheduled to receive cefoxitin as a prophylactic antibiotic
• Exclusion Criteria:
• • Known allergies, hypersensitivity, or intolerance to cefoxitin
• • Patients with a history of receiving cefoxitin within 3 days of the scheduled surgery time
• • Patients receiving therapeutic antibiotics
• • eGFR \< 30 ml/min/1.73m2