A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer
Launched by SEAGEN, A WHOLLY OWNED SUBSIDIARY OF PFIZER · Feb 14, 2022
Trial Information
Current as of June 26, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is testing a new treatment approach for patients with HER2 positive colorectal cancer that has spread to other parts of the body and cannot be surgically removed. The study is comparing a combination of three drugs—tucatinib, trastuzumab, and mFOLFOX6—against the current standard treatments, which may include mFOLFOX6 alone or with other cancer drugs like bevacizumab or cetuximab. Researchers want to see if the new combination works better and what side effects may occur.
To participate in this trial, individuals must have a confirmed diagnosis of colorectal cancer that is either advanced and cannot be removed or metastatic. Key eligibility criteria include having specific test results showing HER2 positive cancer and the right type of tumor genetics. Participants will be randomly assigned to either receive the new drug combination or the standard care treatment. Throughout the study, patients will be monitored for their response to the treatment and any side effects they may experience. This trial is currently recruiting participants aged 65 to 74, and it is open to all genders.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Histologically and/or cytologically confirmed adenocarcinoma of the colon or rectum which is locally advanced unresectable or metastatic
- • Able to provide the most recently available formalin-fixed paraffin-embedded (FFPE) tumor tissue blocks (or freshly sectioned slides) obtained prior to treatment initiation to a central laboratory
- • If archival tissue is not available, a newly-obtained baseline biopsy of an accessible tumor lesion is required within 35 days prior to start of study treatment
- • HER2+ disease as determined by a tissue based assay performed at a central laboratory.
- • Participant has rat sarcoma viral oncogene homolog wild-type (RAS WT) disease as determined by local or central testing. For central RAS analysis, tissue sample must be analyzed within 1 year of biopsy date.
- * Radiographically measurable disease per RECIST v1.1 with:
- • At least one site of disease that is measurable and that has not been previously irradiated, or
- • If the participant has had previous radiation to the target lesion(s), there must be evidence of progression since the radiation
- • Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1
- * CNS Inclusion - based on contrast brain magnetic resonance imaging, participants may have any of the following:
- • No evidence of brain metastases
- • Previously treated brain metastases which are asymptomatic
- Exclusion Criteria:
- • Prior systemic anticancer therapy for colorectal cancer (CRC) in the locally advanced unresectable or metastatic setting; note that participants may have received a maximum of 2 doses of mFOLFOX6 in the locally advanced/unresectable or metastatic setting prior to randomization.
- • Note: May have received chemotherapy for CRC in the adjuvant setting if it was completed \>6 months prior to enrollment
- • Radiation therapy within 14 days prior to enrollment (or within 7 days in the setting of stereotactic radiosurgery)
- • Previous treatment with anti-HER2 therapy
- • Ongoing Grade 3 or higher neuropathy
- • Active or untreated gastrointestinal (GI) perforation at the time of screening.
About Seagen, A Wholly Owned Subsidiary Of Pfizer
Seagen, a wholly owned subsidiary of Pfizer, is a leading biotechnology company dedicated to developing innovative cancer therapies. With a strong focus on targeted therapies and antibody-drug conjugates, Seagen leverages its advanced scientific expertise and robust research capabilities to address the unmet needs of patients with various forms of cancer. The company's commitment to precision medicine and collaboration with healthcare professionals underpins its mission to improve treatment outcomes and enhance the quality of life for cancer patients worldwide. Through rigorous clinical trials and a patient-centric approach, Seagen aims to bring transformative therapies to market, advancing the field of oncology.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Rochester, Minnesota, United States
Los Angeles, California, United States
Durham, North Carolina, United States
Rochester, Minnesota, United States
Brussels, , Belgium
Sioux Falls, South Dakota, United States
Saskatoon, Saskatchewan, Canada
Atlanta, Georgia, United States
Pinehurst, North Carolina, United States
New York, New York, United States
Madrid, , Spain
Miami Beach, Florida, United States
Madrid, , Spain
Madrid, , Spain
Zaragoza, , Spain
Toronto, Ontario, Canada
Portland, Oregon, United States
Saint Paul, Minnesota, United States
Paris, , France
Portland, Oregon, United States
Minneapolis, Minnesota, United States
Scottsdale, Arizona, United States
Barcelona, , Spain
Santander, , Spain
Saint Louis Park, Minnesota, United States
Sapporo, Hokkaido, Japan
Nashville, Tennessee, United States
Denver, Colorado, United States
Paris, , France
Miami Beach, Florida, United States
Toronto, Ontario, Canada
Barcelona, , Spain
Houston, Texas, United States
Los Angeles, California, United States
Seoul, , Korea, Republic Of
Atlanta, Georgia, United States
Phoenix, Arizona, United States
Glendale, Arizona, United States
Harbor City, California, United States
Montreal, Quebec, Canada
Minneapolis, Minnesota, United States
Vancouver, Washington, United States
Louisville, Kentucky, United States
Alicante, , Spain
Valencia, , Spain
Nice Cedex 2, , France
Anaheim, California, United States
Houston, Texas, United States
Denver, Colorado, United States
Anaheim, California, United States
Lexington, Kentucky, United States
Berlin, , Germany
Atlanta, Georgia, United States
Taipei, , Taiwan
La Laguna, Santa Cruz De Tenerife, Spain
Chuo Ku, Tokyo, Japan
Dresden, , Germany
Fitzroy, Victoria, Australia
Cordoba, , Spain
Madrid, , Spain
Amsterdam, , Netherlands
Venlo, , Netherlands
Durham, North Carolina, United States
Erie, Pennsylvania, United States
Sevilla, , Spain
Creteil, , France
Ottawa, Ontario, Canada
Burnsville, Minnesota, United States
Paris, , France
Phoenix, Arizona, United States
Atlanta, Georgia, United States
Everett, Washington, United States
Lleida, , Spain
Tainan, , Taiwan
Leipzig, Sachsen, Germany
Seoul, , Korea, Republic Of
Seoul, , Korea, Republic Of
Seoul, , Korea, Republic Of
Osaka Shi, Osaka, Japan
Atlanta, Georgia, United States
Manchester, , United Kingdom
Pavia, , Italy
Beijing, , China
Seoul, , Korea, Republic Of
Winterthur, , Switzerland
Saint Louis Park, Minnesota, United States
Nashville, Tennessee, United States
Amberg, , Germany
Rouen Cedex, , France
Ulm, , Germany
Canton, Ohio, United States
Sutton, Surrey, United Kingdom
Portland, Oregon, United States
Leuven, , Belgium
Camperdown, New South Wales, Australia
Harbin, , China
Incheon, , Korea, Republic Of
Shenyang, Liaoning, China
London, , United Kingdom
Everett, Washington, United States
Nanchang, Jiangxi, China
Taipei, , Taiwan
Oviedo, , Spain
Milano, , Italy
Pamplona, Navarra, Spain
Los Angeles, California, United States
Zhengzhou, Henan, China
Edegem, , Belgium
Pasadena, California, United States
Changsha, Hunan, China
Poitiers, , France
Houston, Texas, United States
Los Angeles, California, United States
Cambridge, , United Kingdom
Seoul, , Korea, Republic Of
Fuzhou, Fujian, China
Pinehurst, North Carolina, United States
Firenze, , Italy
Pensacola, Florida, United States
Dallas, Texas, United States
Lanzhou, Gansu, China
Haikou, Hainan, China
Harbin, Heilongjiang, China
Pamplona, , Spain
Los Angeles, California, United States
Seoul, , Korea, Republic Of
Glendale, Arizona, United States
Nanchang, Jiangxi, China
Anderlecht, , Belgium
Melbourne, Victoria, Australia
Wiener Neustadt, , Austria
Toronto, Ontario, Canada
Jinan, Shandong, China
Riverside, California, United States
Aurora, Colorado, United States
London, , United Kingdom
Paris, Texas, United States
Pisa, , Italy
Chengde, Hebei, China
Tigard, Oregon, United States
Leuven, , Belgium
Salem, Virginia, United States
Oviedo, Asturias, Spain
Nantes Cedex 1, , France
Boulder, Colorado, United States
Guangzhou, Guangdong, China
Avignon Cedex 9, , France
Matsuyama Shi, , Japan
Frankfurt, , Germany
Kita Gun, Kagawa, Japan
Pisa, Toscana, Italy
Glendale, California, United States
Irving, Texas, United States
Irving, Texas, United States
Irving, Texas, United States
Suita Shi, Osaka Fu, Japan
Hangzhou, Zhejiang, China
Lakewood, Colorado, United States
Roma, Lazio, Italy
Brescia, Lombardia, Italy
Hangzhou, Zhejiang, China
Edina, Minnesota, United States
Xuzhou, Jiangsu, China
Changsha, Hunan, China
Warszawa, Mazowieckie, Poland
Butler, Pennsylvania, United States
Monroeville, Pennsylvania, United States
Los Angeles, California, United States
Phoenix, Arizona, United States
Almada, , Portugal
Hamburg, , Germany
Kobe Shi, , Japan
Changzhou, Jiangsu, China
Jinan, Shandong, China
Szekszard, , Hungary
Los Angeles, California, United States
London, , United Kingdom
Baldwin Park, California, United States
Fontana, California, United States
Panorama City, California, United States
Woodland Hills, California, United States
Kashiwa Shi, Chiba Ken, Japan
Dublin, , Ireland
Lisboa, , Portugal
Louisville, Kentucky, United States
Louisville, Kentucky, United States
San Marcos, California, United States
Miami Beach, Florida, United States
Paris, Texas, United States
Chiba Shi, Chiba Ken, Japan
Hannover, Niedersachsen, Germany
Matsuyama Shi, Ehime Ken, Japan
Harrison, New York, United States
Newport Beach, California, United States
Bellflower, California, United States
Durham, North Carolina, United States
Meizhou, Guangdong, China
Lyon Cedex 3, , France
Zaragoza, , Spain
Shanghai, , China
Wuhan, Hubei, China
Jinzhou, Liaoning, China
Suzhou, Jiangsu, China
Santa Rosa, California, United States
Brussels, Other, Belgium
Edegem, Other, Belgium
Dijon, Other, France
Paris, Other, France
Barcelona, Other, Spain
Madrid, Other, Spain
Shanghai, Shanghai, China
Mckinney, Texas, United States
Louisville, Kentucky, United States
Shenyang, Liaoning, China
Kitaadachi Gun, Saitama, Japan
Pittsburgh, Pennsylvania, United States
Coon Rapids, Minnesota, United States
Takatsuki Shi, Osaka, Japan
Canton, Ohio, United States
Viña Del Mar, , Chile
Muenchen, Other, Germany
Seoul, Other, Korea, Republic Of
Madrid, Other, Spain
Lone Tree, Colorado, United States
Newberg, Oregon, United States
Portland, Oregon, United States
Portland, Oregon, United States
Pittsburgh, Pennsylvania, United States
Washington, Pennsylvania, United States
Louisville, Kentucky, United States
Madrid, Other, Spain
Waterford, , Ireland
Louisville, Kentucky, United States
Cork, , Ireland
Pavia, Other, Italy
Barcelona, Other, Spain
Oviedo, Other, Spain
Wilton, Other, Ireland
Milano, Other, Italy
Munchen, , Germany
Jinan, , China
Koto Ku, Tokyo, Japan
Osakasayama Shi, Osaka, Japan
Tangshan, Hebei, China
Louisville, Kentucky, United States
Anderlecht, Other, Belgium
Ottawa, Ontario, Canada
Chiba, Other, Japan
Chuo Ku, Other, Japan
Kitaadachi Gun, Other, Japan
Yokohama, Other, Japan
Seoul, Other, Korea, Republic Of
Amsterdam, Other, Netherlands
Cordoba, Other, Spain
Sevilla, Other, Spain
Zaragoza, Other, Spain
Tainan, Other, Taiwan
London, Other, United Kingdom
Manchester, Other, United Kingdom
Newcastle Upon Tyne, Other, United Kingdom
Saint Louis Park, Minnesota, United States
Taipei, Other, Taiwan
Glasgow, Other, United Kingdom
München, , Germany
Yokohama Shi, Kanagawa, Japan
Paris, Texas, United States
Dublin, , Ireland
Salzburg, , Austria
Malaga, , Spain
La Louvière, Other, Belgium
Brest Cedex, Other, France
Nice Cedex 2, Other, France
Napoli, Other, Italy
Tricase, Other, Italy
Incheon, Other, Korea, Republic Of
Madrid, Other, Spain
Pamplona, Other, Spain
London, Other, United Kingdom
Kawasaki Shi, Other, Japan
Verona, Other, Italy
Linyi, Shandong, China
Kashiwa Shi, Other, Japan
Dresden, , Germany
Strasbourg, , France
Barcelona, Other, Spain
Santa Rosa, California, United States
Haikou, Hainan, China
Nanyang, Henan, China
Middletown, New Jersey, United States
Montvale, New Jersey, United States
Uniondale, New York, United States
Dublin, , Ireland
Alicante, Other, Spain
Guangzhou, , China
Kawasaki Shi, Kanagawa, Japan
Basking Ridge, New Jersey, United States
New York, New York, United States
Seoul, Songpa Gu,, Korea, Republic Of
Saint Louis Park, Minnesota, United States
Roanoke, Virginia, United States
Wuhan, Other, China
Besancon Cedex, Other, France
Roanoke, Virginia, United States
Córdoba, Other, Argentina
Commack, New York, United States
Avignon, Other, France
Louisville, Kentucky, United States
Jaú, Other, Brazil
Strasbourg, Other, France
Hangzhou, Other, China
Fukuoka Shi, Other, Japan
Rochester, Minnesota, United States
Maplewood, Minnesota, United States
Nanchang, Other, China
Poprad, Other, Slovakia
Changsha, Other, China
Waterford, Other, Ireland
São Paulo, Other, Brazil
Chengde, Other, China
Osakasayama Shi, Other, Japan
Rosario, Santa Fe, Argentina
Porto Alegre, Other, Brazil
Santo Andre, Other, Brazil
Jinan, Other, China
Seoul, Other, Korea, Republic Of
Kansas City, Missouri, United States
Fitzroy, Other, Australia
Seoul, Other, Korea, Republic Of
London, Other, United Kingdom
Melbourne, Other, Australia
Townsville, Other, Australia
Taipei City, Other, Taiwan
Cottingham, Other, United Kingdom
Santander, Other, Spain
Seoul, Other, Korea, Republic Of
Barretos, Other, Brazil
Sao Jose Rio Preto, Other, Brazil
Linyi, Other, China
Shenyang, Other, China
Harbin, Other, China
Xuzhou, Other, China
Zhengzhou, Other, China
Ciudad Autonoma Buenos Aires, Other, Argentina
Guangzhou, Other, China
Meizhou, Other, China
Nanyang, Other, China
Valencia, Other, Spain
Ourense, Other, Spain
Lleida, Other, Spain
Changsha, Other, China
Taoyuan, Other, Taiwan
Viña Del Mar, Other, Chile
Nanchang, Other, China
Tangshan, Other, China
Shenyang, Other, China
Santiago, Other, Chile
Haikou, Other, China
Bristol, , United Kingdom
Hangzhou, Other, China
Kita Gun, Other, Japan
Matsuyama Shi, Other, Japan
Osaka Shi, Other, Japan
Leeds, Other, United Kingdom
Fuzhou, Fujian, China
Malaga, Other, Spain
Denver, Colorado, United States
Anaheim, California, United States
Merriam, Kansas, United States
Haikou, Other, China
Sapporo Shi, Other, Japan
Konin, Other, Poland
Kita Gun, , Japan
Lanzhou, Other, China
Koto Ku, Other, Japan
Dublin, , Ireland
Fuzhou, Other, China
Taiyuan, Other, China
Venlo, Other, Netherlands
Rosario, Other, Argentina
Shanghai, Other, China
Winterthur, Other, Switzerland
Cordoba, Other, Argentina
Jinzhou, Other, China
Suzhou, Other, China
Kaohsiung City, Other, Taiwan
Taiyuan, Shanxi, China
Barcelona, Other, Spain
Nieuwegein, Other, Netherlands
Kobe Shi, Other, Japan
Dublin, Other, Ireland
Takatsuki Shi, Other, Japan
Bratislava, Other, Slovakia
Bristol, Other, United Kingdom
Newport Beach, California, United States
Zürich, Other, Switzerland
Pinehurst, North Carolina, United States
Paris Cedex 10, Other, France
Saint Priest En Jarez, Other, France
Suita Shi, Other, Japan
St Herblain, Other, France
Nantes, Other, France
Poitiers, Other, France
Dublin, Other, Ireland
Dublin, , Ireland
Bergen, Other, Norway
Oslo, Other, Norway
Lodz, Other, Poland
Changzhou, Other, China
Littleton, Colorado, United States
Haidari, Other, Greece
Salzburg, Other, Austria
Wels, Other, Austria
Lyon, Other, France
Paris, Other, France
Avellino, Other, Italy
Brescia, Other, Italy
Padova, Other, Italy
Pisa, Other, Italy
Marseille, Other, France
Avellino, , Italy
Chongqing, Other, China
Fuzhou, Other, China
Catania, Other, Italy
Warsaw, Other, Poland
Osaka Shi, Other, Japan
Gdansk, Other, Poland
Caba, , Argentina
Haine Saint Paul, Other, Belgium
Liège, Other, Belgium
Changzhou, Other, China
Dresden, Other, Germany
Mönchengladbach, Other, Germany
Milano, Other, Italy
Roma, Other, Italy
Milano, Other, Italy
Madrid, Other, Spain
Los Angeles, California, United States
Pergamino, Other, Argentina
München, Other, Germany
Curitiba, Other, Brazil
Toronto, Ontario, Canada
Cork, Other, Ireland
Oslo, Other, Norway
Hamburg, , Germany
Turnhout, Other, Belgium
Rouen, Other, France
Guarda, Other, Portugal
Lisboa, Other, Portugal
Foggia, Other, Italy
Sondrio, Other, Italy
Athens, Other, Greece
Padova, Veneto, Italy
San Diego, California, United States
Shanghai, Other, China
Pessac, Other, France
Monserrato, Other, Italy
Porto, Other, Portugal
Madrid, Other, Spain
Concepción, Other, Chile
Roma, Other, Italy
Rio De Janeiro, Other, Brazil
Hannover, Other, Germany
Atlanta, Georgia, United States
Ciudad Autonoma Buenos Aires, Other, Argentina
Madrid, Other, Spain
Jaú, Other, Brazil
Porto Alegre, Other, Brazil
Sao Jose Rio Preto, Other, Brazil
São Paulo, Other, Brazil
Liège, Other, Belgium
Concepción, Other, Chile
Santiago, Other, Chile
Porto, Other, Portugal
Zurich, Other, Switzerland
Dresden, Other, Germany
Maplewood, Minnesota, United States
Szekszard, Other, Hungary
Rzeszow, Other, Poland
Cork, Other, Ireland
Dublin 4, Other, Ireland
Naploli, Other, Italy
Brest, , France
Reggio Emilia, Other, Italy
Utrecht, , Netherlands
Roanoke, Virginia, United States
Haine Saint Paul, , Belgium
Amberg, Other, Germany
Frankfurt Am Main, Other, Germany
Hamburg, Other, Germany
Surrey, Other, United Kingdom
Berlin, Other, Germany
Hamburg, Other, Germany
Ulm, Other, Germany
Foggia, Other, Italy
Wiener Neustadt, Other, Austria
Leipzig, Other, Germany
Dublin, Other, Ireland
Genova, Other, Italy
Valencia, Other, Spain
Pessac, , France
Barcelona, Other, Spain
Coon Rapids, Minnesota, United States
Edina, Minnesota, United States
Minneapolis, Minnesota, United States
Robbinsdale, Minnesota, United States
Portland, Oregon, United States
Milano, Lombardy, Italy
Kobe Shi, Hyōgo, Japan
Oslo, , Norway
Oslo, , Norway
Viña Del Mar, Valparaíso, Chile
Meizhou, Guangdong, China
Fukuoka City, Fukuoka, Japan
Konin, Wielkopolskie, Poland
Anaheim, California, United States
Irvine, California, United States
Los Angeles, California, United States
Los Angeles, California, United States
Ontario, California, United States
Pasadena, California, United States
San Diego, California, United States
Van Nuys, California, United States
Colorado Springs, Colorado, United States
Longmont, Colorado, United States
Pueblo, Colorado, United States
Thornton, Colorado, United States
Aventura, Florida, United States
Atlanta, Georgia, United States
Merriam, Kansas, United States
Fridley, Minnesota, United States
Maple Grove, Minnesota, United States
Saint Louis Park, Minnesota, United States
Saint Paul, Minnesota, United States
Woodbury, Minnesota, United States
New York, New York, United States
Oregon City, Oregon, United States
Blacksburg, Virginia, United States
Low Moor, Virginia, United States
Wytheville, Virginia, United States
Pergamino, Buenos Aires, Argentina
Ciudad Autónoma De Buenos Aires, , Argentina
Cordoba, , Argentina
Cordoba, , Argentina
Townsville, Queensland, Australia
Wels, Upper Austria, Austria
Salzburg, , Austria
Haine Saint Paul, , Belgium
Liège, , Belgium
Turnhout, , Belgium
Turnhout, , Belgium
Curitiba, Parana, Brazil
Porto Alegre, Rio Grande Do Sul, Brazil
Rio De Janeiro, Rj, Brazil
Barretos, Sao Paulo, Brazil
Jau, Sao Paulo, Brazil
Santo Andre, Sao Paulo, Brazil
Sao Jose Do Rio Preto, Sp, Brazil
Sao Paulo, , Brazil
Concepcion, , Chile
Santiago, , Chile
Chengde City, Hebei, China
Changzhou, Jiangsu, China
Taiyuan, Shanxi, China
Chongqing, , China
Dijon, , France
Marseille Cedex 8, , France
Paris, , France
Saint Herblain, , France
Saint Priest En Jarez, , France
Muenchen, Bavaria, Germany
München, Bayern, Germany
Bayreuth, Ludwigstraße, Germany
Darmstadt, Luisenplatz, Germany
Amberg, Mariahilfbergweg, Germany
Leipzig, Saxony, Germany
Dresden, , Germany
Dresden, , Germany
Frankfurt, , Germany
Hamburg, , Germany
Hamburg, , Germany
Muenchen, , Germany
Mönchengladbach, , Germany
Neuss, , Germany
Psychiko, Athens, Greece
Athens, Attikí, Greece
Athens, Chaidari, Greece
Heraklion, Crete, Greece
Nea Efkarpia, Thessaloniki, Greece
Athens, , Greece
Psychiko, , Greece
Cork, , Ireland
Monserrato, Cagliari, Italy
Monserrato, Cagliari, Italy
Avellino, Campania, Italy
Genova, Ge, Italy
Tricase, Lecce, Italy
Milano, Lombardy, Italy
Milano, Lombardy, Italy
Napoli, Naples, Italy
Genova, Other, Italy
Pisa, Other, Italy
Verona, Other, Italy
Reggio Emilia, Re, Italy
Catania, Sicily, Italy
Firenze, Tuscany, Italy
Foggia, , Italy
Milano, , Italy
Milan, , Italy
Padova, , Italy
Pavia, , Italy
Reggio Emilia, , Italy
Reggio Emilia, , Italy
Roma, , Italy
Sondrio, , Italy
Sondrio, , Italy
Verona, , Italy
Chuo Ku, Osaka, Japan
Amsterdam, , Netherlands
Nieuwegein, , Netherlands
Bergen, , Norway
Bergen, , Norway
Warszawa, Mazowieckie, Poland
Warszawa, Mazowieckie, Poland
Rzeszow, Podkarpackie, Poland
Rzeszow, Podkarpackie, Poland
Gdansk, Pomorskie, Poland
Lodz, , Poland
Guarda, , Portugal
Porto, , Portugal
Bratislava, , Slovakia
L'hospitalet De Llobregat, Barcelona, Spain
Barcelona, , Spain
Barcelona, , Spain
Barcelona, , Spain
Ourense, , Spain
Winterthur, Other, Switzerland
Schlieren, , Switzerland
Zurich, , Switzerland
Kaohsiung City, , Taiwan
Tainan, , Taiwan
Taipei, , Taiwan
Taipei, , Taiwan
Taoyuan, , Taiwan
Newcastle Upon Tyne, Chelsea, United Kingdom
Cambridge, England, United Kingdom
Leeds, West Yorkshire, United Kingdom
Leeds, , United Kingdom
London, , United Kingdom
London, , United Kingdom
Beaver, Pennsylvania, United States
Greensburg, Pennsylvania, United States
Harrisburg, Pennsylvania, United States
Irwin, Pennsylvania, United States
Irwin, Pennsylvania, United States
Mechanicsburg, Pennsylvania, United States
Pittsburgh, Pennsylvania, United States
Pittsburgh, Pennsylvania, United States
Oslo, , Norway
Warszawa, Mazowieckie, Poland
Madrid, Madrid, Comunidad De, Spain
Athens, , Greece
Madrid, , Spain
Patients applied
Trial Officials
Pfizer CT.gov Call Center
Study Director
Pfizer
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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