The InterVitaminK Trial - Effects of Vitamin K Supplementation on Cardiovascular, Metabolic, and Bone Health

Launched by BISPEBJERG HOSPITAL · Feb 18, 2022

Keywords

ClinConnect Summary

The InterVitaminK Trial is a study aimed at understanding how taking a supplement called menaquinone-7 (MK-7), a form of Vitamin K, may affect heart health, metabolism, and bone health. Researchers want to see if MK-7 can help people with a condition called coronary artery calcification (CAC), where calcium builds up in the heart's arteries, making them stiff and less flexible. The study is currently looking for participants aged between 18 and 75 who have been identified with detectable CAC through a specific heart scan.

To be eligible for the trial, participants must not have a history of serious heart diseases or certain other health conditions, such as active cancer or coagulation disorders, and they should not be taking other Vitamin K supplements. Those who join the study will take MK-7 supplements and may help to provide important information on how Vitamin K impacts cardiovascular and bone health. If you're interested in participating, this trial could be an opportunity to contribute to valuable research while helping to improve your own health outcomes.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Detectable CAC (Agatson score \>=10) assessed by Cardiac Computed Tomography (CT) scan in the Inter99 20-year follow-up study
• Exclusion Criteria:
• • Manifest CVD (prior cerebral infarct, prior myocardial infarct, prior percutaneous coronary intervention or prior coronary artery bypass surgery)
• • Noise on the CT scan, which complicates an accurate assessment of CAC and interpretation of the CT scan. An example is a pacemaker
• • Current treatment with Vitamin K antagonist (VKA).
• • History of coagulation disorders (hemophilia, von Willebrand disease, sickle cell anemia)
• • Active malignant disease (ongoing treatment)
• • Previous surgical removal of the thyroid gland, or one or more of the parathyroid glands
• • Regular use of vitamin K supplements other than trial tablets
• • Pregnancy or breastfeeding