Diffusion MRI of the Abdomen

Launched by UNIVERSITY OF WISCONSIN, MADISON · Feb 17, 2022

Keywords

ClinConnect Summary

This clinical trial is studying a new way to take pictures of the abdomen using magnetic resonance imaging (MRI). The goal is to improve the quality of these images by reducing blurriness caused by movements like breathing or heartbeat. Researchers will first test this new method on healthy volunteers and then check its effectiveness on patients who have liver tumors that can be seen on standard scans.

To participate, you need to be at least 18 years old. Healthy volunteers should not have any conditions that make MRIs unsafe, such as having a pacemaker or severe claustrophobia. Patients with liver tumors must also meet certain criteria, including having at least one tumor that is 1 cm or larger and has not been treated recently. Participants will undergo a single MRI session, and those who may need mild anxiety medication can still join as long as they follow specific guidelines. It’s important to note that pregnant individuals or those trying to become pregnant cannot participate in this study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria for Healthy Volunteers:
• • 18 years of age or older
• Exclusion Criteria for Healthy Volunteers:
• • Patients with contraindication to MRI (e.g. pacemaker, contraindicated metallic implants, claustrophobia, etc)
• • Pregnant or trying to become pregnant (as determined by self-report during MRI safety screening)
• Inclusion Criteria for Patients:
• • 18 years of age or older
• * Radiologically visible solid tumor liver metastasis:
• • At least one metastatic liver lesion must be a minimum of 1 cm in longest diameter
• Exclusion Criteria for Patients:
• • Patients with contraindication to MRI (e.g. pacemaker, contraindicated metallic implants, claustrophobia, etc)
• • Patients with known contraindication to GBCA such as severe kidney disease or previously documented GFR \< 30 ml/min/1.73 m2
• * Patients requiring intravenous (IV) conscious sedation for imaging are not eligible; patients requiring mild, oral anxiolytics for the MRI will be allowed to participate as long as the following criteria are met:
• • The subject has their own prescription for the medication.
• • The informed consent process is conducted prior to the self-administration of this medication
• • They come to the research visit with a driver
• • Pregnant or trying to become pregnant (as determined by self-report during MRI safety screening)
• • Stent in bile ducts
• • Partial hepatectomy