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Search / Trial NCT05263765

Aortic Occlusion for Resuscitation in Trauma and Acute Care Surgery

Launched by METHODIST HEALTH SYSTEM · Feb 21, 2022

Trial Information

Current as of July 12, 2025

Enrolling by invitation

Keywords

ClinConnect Summary

An evolution in endovascular technologies, however, has provided additional means by which to achieve AO. Expanding experience with the utilization of balloon occlusion in the setting of abdominal aortic rupture due to chronic vascular disease has demonstrated the potential of these new technologies. Discussion of the employment of endovascular AO in the realm of trauma has led to the description of this approach and the demonstration of its effectiveness in animal models of severe hemorrhage.

The purpose of the present study is to prospectively examine the modern utilization of AO in the ...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • All adult (age ≥ 18 years) trauma and acute care surgery patients treated with resuscitative AO (via open or endovascular means) in the acute phases after injury
  • Transient or refractory hypotension (systolic blood pressure \<90mmHg) with a positive abdominal focused abdominal sonography in trauma (FAST) scan, severe pelvic fracture(s), or neither with persistent hypotension without obvious source
  • Chest x-ray without evidence of thoracic aortic injury
  • Subject treatment includes internal aortic cross-clamp or would have likely benefited from an internal aortic cross-clamp
  • Exclusion Criteria:
  • Subject \< 18 years of age
  • Prisoner
  • Evidence of cardiac, thoracic aortic, or great vessel injury identified in primary survey, FAST scan, and/or x-rays
  • Any open/exsanguinating upper extremity wound

About Methodist Health System

Methodist Health System is a leading healthcare provider dedicated to advancing medical research and improving patient outcomes through innovative clinical trials. With a commitment to excellence in patient care and scientific inquiry, the organization leverages its state-of-the-art facilities and multidisciplinary expertise to conduct rigorous studies across various therapeutic areas. Methodist Health System collaborates with healthcare professionals, researchers, and industry partners to enhance the understanding of diseases and develop new treatment modalities, ensuring that cutting-edge therapies are accessible to the communities it serves. Through its clinical trial initiatives, Methodist Health System aims to contribute to the evolving landscape of medicine while prioritizing patient safety and ethical standards.

Locations

Dallas, Texas, United States

Patients applied

0 patients applied

Trial Officials

Conner McDaniel, M.D.

Principal Investigator

Methodist Health System

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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