Assessment of Endothelial Glycocalyx in Patients With Primary Open-angle Glaucoma

Launched by FONDATION OPHTALMOLOGIQUE ADOLPHE DE ROTHSCHILD · Mar 2, 2022

Keywords

ClinConnect Summary

This clinical trial is studying a special layer of cells called the glycocalyx, which lines the inside of blood vessels and plays a crucial role in maintaining healthy blood flow and preventing clotting. Researchers want to understand how this layer may be affected in people with primary open-angle glaucoma, a common eye condition that can gradually damage vision. By examining the glycocalyx in patients with glaucoma, the study aims to see if changes in this layer could help explain the damage caused by the disease and potentially serve as a new way to assess glaucoma's progression.

To participate in this study, individuals aged 65 and older who have been diagnosed with primary open-angle glaucoma may be eligible, provided they agree to join the study. There is also a control group for those without any optic nerve issues. Participants will undergo various tests to assess their condition and the state of their glycocalyx. It’s important to note that certain health conditions, such as pregnancy, recent strokes, or specific diseases, may exclude individuals from participating. Overall, this study hopes to shed light on the connection between the glycocalyx and glaucoma, which could lead to better ways to diagnose and treat this eye condition in the future.

Gender

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Eligibility criteria

• Inclusion Criteria:
• • Express consent to participate in the study
• • Only for case group: primary open angle glaucoma (defined as the presence of visual field damage attributed to glaucomatous optic neuropathy) in both eyes
• • Only for control group: Absence optic nerve pathology (including primary open angle glaucoma)
• Exclusion Criteria:
• • Pregnant or breastfeeding woman
• • Sleep apnea
• • Renal insufficiency
• • Parkinson's disease
• • Alzheimer's disease
• • Antiphospholipid syndrome
• • Cancer for which treatment ended less than 2 years ago
• • Stroke less than 1 year ago
• • Myocardial infarction less than 1 year ago