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Search / Trial NCT05266092

Activation of the Contact System and the Immune System in Patients With Chronic Kidney Disease.

Launched by ODENSE UNIVERSITY HOSPITAL · Feb 23, 2022

Trial Information

Current as of July 26, 2025

Recruiting

Keywords

Contact System Infection Innate Immune System Coagulation Chronic Kidney Disease Hemodialysis End Stage Renal Disease

ClinConnect Summary

This clinical trial is studying why patients with chronic kidney disease who are on hemodialysis (a type of kidney treatment) have a higher risk of severe infections and complications, particularly from a bacteria called Staphylococcus aureus. The researchers believe that the process of hemodialysis may weaken the immune system and make it harder for patients to fight off infections. They will collect blood samples from participants to look at levels of inflammation and blood clotting before and after dialysis, comparing these results to those from healthy individuals and other patients with kidney issues.

To be eligible for this trial, participants must be over 18 years old and have chronic kidney disease. This includes those currently undergoing hemodialysis, those with kidney disease not on dialysis, and those using another treatment called peritoneal dialysis. The study is currently recruiting participants, and if you join, you can expect to provide blood samples and help researchers learn more about how to better protect patients like you from infections during treatment.

Gender

ALL

Eligibility criteria

  • Participants with chronic kidney disease undergoing hemodialysis Inclusion criteria
  • Age \>18 years
  • Chronic kidney disease
  • Hemodialysis
  • Exclusion criteria:
  • - Acute kidney disease
  • Participants with chronic kidney disease, not in dialysis Inclusion criteria
  • Age \>18 years
  • Chronic kidney disease (eGFR from \<15 to 44)
  • Exclusion criteria:
  • Acute kidney disease
  • Hemodialysis
  • Peritoneal dialysis
  • Participants with chronic kidney disease undergoing peritoneal dialysis Inclusion criteria
  • Age \>18 years
  • Chronic kidney disease
  • Peritoneal dialysis
  • Exclusion criteria:
  • - Acute kidney disease
  • Healthy volunteers Inclusion criteria
  • Age \>18 years
  • Blooddonors
  • Exclusion criteria:
  • - NA

About Odense University Hospital

Odense University Hospital is a leading academic medical center located in Denmark, dedicated to advancing healthcare through innovative research and clinical trials. As a prominent sponsor of clinical studies, the hospital is committed to enhancing patient outcomes and fostering collaboration among multidisciplinary teams. With a focus on translating scientific discoveries into practical applications, Odense University Hospital leverages its state-of-the-art facilities and expertise to conduct rigorous trials across various medical fields, ensuring adherence to the highest ethical and regulatory standards. Through these efforts, the hospital aims to contribute significantly to the global body of medical knowledge and improve the quality of care for patients both locally and internationally.

Locations

Odense, , Denmark

Odense, , Denmark

Patients applied

0 patients applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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