Oral Immunonutrition With Synbiotics, Omega 3 and Vitamin D in Patients Undergoing Duodenopancreatectomy for Tumoral Lesion.

Launched by CENTRE HOSPITALIER UNIVERSITAIRE DE LIEGE · Mar 4, 2022

Keywords

ClinConnect Summary

This clinical trial is looking at a special type of nutrition called synbioimmunonutrition, which combines beneficial bacteria (probiotics), omega-3 fatty acids (found in fish oil), and vitamin D. The goal is to see if this nutrition plan can help patients who are about to have surgery for pancreatic cancer (specifically a procedure called duodenopancreatectomy) recover better than if they follow the usual nutrition plan for a week before surgery. Researchers believe that this new approach could reduce complications and improve overall health after surgery.

To participate in this trial, patients need to be scheduled for a duodenopancreatectomy for a tumor. However, there are some important requirements: patients who have had certain types of pancreatic surgery before, those with severe health issues, or anyone who cannot eat by mouth may not be eligible. Participants will receive the special nutrition plan before their surgery and will be monitored to see how well it works in helping them recover. If you or a loved one is considering this trial, it's a chance to potentially benefit from an innovative approach to care during a challenging time.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • All cases of duodenopancreatectomy for tumoral lesions.
• Exclusion Criteria:
• • Distal or total pancreatectomies, as well as procedures for chronic pancreatitis
• • Patient refusal or inability to provide informed consent
• • Use of dietary supplements containing omega 3, pre- or probiotics within 15 days prior to protocol initiation
• • Severe cardiorespiratory or renal insufficiency
• • HIV
• • Cirrhosis Child-Pugh B-C
• • Inability to feed by mouth
• • Intestinal obstruction
• • Unresectable tumor or metastatic disease on preoperative work-up
• • Cardiac valvular pathology
• • Short bowell syndrome
• • Haemophilia
• • Known allergy or intolerance to fish oil, fish or shellfish, milk, soy or components of the products used
• • BMI \< 16kg/m2
• • Weight loss \> 15% in the last 6 months
• • Little or no food in the last 10 days
• • Hypercalcemia
• • Pregnancy, breastfeeding