Investigation of Cerebral Motor Activity Modulations Following Median Nerve Stimulation During General Anaesthesia

Launched by BRUGMANN UNIVERSITY HOSPITAL · Feb 28, 2022

Keywords

ClinConnect Summary

This clinical trial, called STIM-MOTANA, is studying how brain activity changes when a specific nerve is stimulated in patients undergoing general anesthesia. The researchers aim to find out if this stimulation can help detect if a patient is aware during surgery, which can happen to about 1-2% of high-risk patients. This situation, known as Accidental Awareness During General Anesthesia, can lead to severe psychological issues, including post-traumatic stress disorder (PTSD). By monitoring brain signals while stimulating the median nerve, the team hopes to create a better way to alert anesthesiologists if a patient is trying to move, indicating they might be aware.

To be eligible for this trial, participants must be right-handed adults aged 18 to 80 who are scheduled for surgery that requires intravenous anesthesia with propofol. However, certain individuals, such as those with allergies to propofol, specific health conditions, or past injuries affecting the right arm, cannot participate. During the study, 30 patients will have their brain activity measured while receiving different doses of propofol and undergoing median nerve stimulation. After the surgery, the researchers will monitor how the brain's electrical signals change with varying levels of anesthesia. This study is currently recruiting participants, and your involvement could help improve safety during surgeries in the future.

Gender

MALE

Eligibility criteria

• Inclusion Criteria:
• • Patients \>18 years and \<81 years
• • Right-handed
• • Programmed for surgery with the use of an intravenous anesthesia with a propofol concentration objective
• Exclusion Criteria:
• • Allergy to propofol, soy or peanuts
• • BMI\<20 or \>30
• • Pregnant or breastfeeding women
• • Adult unable to give consent
• • Medical or surgical history that may interfere with median nerve stimulation or the obtention of the EEG signal (for example: diabetes, polyneuropathy, central neurodegenerative disease, epilepsy, brain surgery)
• • History of right median nerve injury
• • Amputation of the upper right limb
• • Impossibility of affixing an EEG helmet
• • Addiction