Coronary Microvascular Dysfunction Assessments in Myocardial Infarction With Non-Obstructive Coronary Arteries

Launched by CHONNAM NATIONAL UNIVERSITY HOSPITAL · Feb 28, 2022

Keywords

ClinConnect Summary

This clinical trial is studying a specific type of heart attack known as myocardial infarction with non-obstructive coronary arteries (MINOCA). It aims to understand how problems in the small blood vessels of the heart, called coronary microvascular dysfunction (CMD), affect recovery and outcomes for patients who experience this type of heart attack. Researchers will use advanced imaging techniques and tests to evaluate the heart's function and blood flow.

To be eligible for this study, participants must be at least 19 years old and have recently suffered a heart attack, with signs of heart muscle damage but without significant blockages in their coronary arteries. They should not have a history of heart disease or other serious conditions that could interfere with the study. Those who join can expect to undergo various assessments to help understand their condition better and may contribute to important findings in heart health. This trial is currently recruiting participants, and both men and women are welcome to apply.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Subject with age ≥19 years and acute myocardial infarction
• • Rise and/or fall of cardiac troponin with one level \>99 percentile plus ischemic signs/symptoms
• • Subject with non-obstructive coronary arteries
• • \<50% diameter stenosis or
• • fractional flow reserve (FFR) \>0.80 ③ Subject without previous history of coronary artery disease
• • Subject who performed invasive coronary angiography within 24 hours after presentation ⑤ Subject who eligible for invasive and non-invasive coronary physiologic assessment
• Exclusion Criteria:
• • Subject with obstructive coronary arteries
• • Subject with alternate diagnosis including sepsis, pulmonary embolism, myocarditis, Takotsubo syndrome, spontaneous coronary dissection, and other cardiomyopathies.
• • Subject with cardiogenic shock or cardiac arrest ④ Subject who has non-cardiac co-morbid conditions with life expectancy \<1 year ⑤ Subject or lactating women ⑥ Subject unable to provide consent