Role of Photic and Non-photic Time Cues in Resetting Circadian Rhythms

Launched by BRIGHAM AND WOMEN'S HOSPITAL · Mar 3, 2022

Keywords

ClinConnect Summary

This clinical trial is studying how different types of time cues, specifically light exposure and meal timing, can help reset our body’s internal clock, known as circadian rhythms. This is important because our circadian rhythms affect things like sleep patterns and metabolism. The researchers want to find out whether light or the timing of meals is more effective in adjusting these rhythms.

To participate in this study, you need to be between 18 and 30 years old, healthy, and not have any major medical or sleep disorders. You should also be a non-smoker and able to keep a consistent sleep schedule for eight hours during the trial. Participants will need to avoid caffeine, alcohol, and certain medications during the study. If you meet these criteria, you can expect to take part in activities that will help the researchers understand how light and meal timing affect your body’s rhythms. It's a chance to contribute to important research on how our bodies work and potentially improve health outcomes for others.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Aged between 18-30 years
• • Healthy (no medical, psychiatric or sleep disorders;
• • Non-smoking for at least 6 months;
• • Body Mass Index of \>18 or \<30 kg/m2;
• • Able to maintain 8-hour consistent sleep schedule during the study
• • Able to refrain from caffeine, alcohol, medication and supplements during the study
• Exclusion Criteria:
• • History of alcohol or substance abuse;
• • Positive result on drugs of abuse urine toxicology;
• • Current or past history of sleep disorders, including but not limited to obstructive sleep apnea, narcolepsy, insomnia, or any significant sleep complaint
• • Psychiatric disorder, or first degree relative with a psychiatric disorder
• • Recent acute or chronic medical disorder
• • Use of drugs or medication (birth control OK) likely to affect sleep, alertness or light sensitivity, as determined by the investigators
• • Visual disorder, including but not limited to color blindness, or family history of glaucoma
• • Pregnancy or lactation
• • Shift work (past 3 years)
• • Transmeridian travel (2 or more time zones) in the past 3 months
• • Any other reason as determine by the Principal Investigator