Complex Molecular Etiology and Cellular Landscape of Hip Osteoarthritis

Launched by UNIVERSITY OF TURKU · Mar 3, 2022

Keywords

ClinConnect Summary

This clinical trial is focused on understanding hip osteoarthritis, a painful condition that affects the hip joint. Researchers are using new techniques to study the complex causes and cell behaviors in this condition. They aim to gather information from patients who are having surgery to replace their hip joints, which will help them learn more about how osteoarthritis develops and how it might be treated in the future.

To participate in this study, adults aged 65 to 74 who have osteoarthritis in their hip and are scheduled for hip replacement surgery may be eligible. Additionally, there is a sub-study for patients with rheumatoid arthritis, another type of joint condition. Participants should know that they will be asked to provide information during their surgery, and certain health conditions, like diabetes or obesity, may prevent them from joining. Overall, this study seeks to improve our understanding of hip osteoarthritis and potentially lead to better treatments.

Gender

ALL

Eligibility criteria

• Inclusion Criteria for the main (OA) study:
• • Cases: Adult patients with osteoarthritis in the hip joint and who are going through an elective total hip arthroplasty.
• • Controls: Non-arthritis adult patients who are going through a trauma-based emergency total hip arthroplasty.
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• Inclusion Criteria for the Rheumatoid sub-study:
• • Adult patients with rheumatoid arthritis in the hip joint and who are going through an elective total hip arthroplasty.
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• Exclusion Criteria:
• • The body mass index must be below 35
• • Age \< 18 or \> 74
• • The OA patients may not have diabetes, rheumatoid arthritis (RA), or metabolic syndrome.
• • For the Rheumatoid sub-study, the exclusion criteria are the same as above except for the RA.