Trained Immunity in Thyroid Carcinoma and Colon Carcinoma

Launched by RADBOUD UNIVERSITY MEDICAL CENTER · Mar 13, 2022

Keywords

ClinConnect Summary

This clinical trial is exploring how the immune system can be trained to better fight certain types of cancer, specifically thyroid cancer and colon cancer. Researchers believe that by understanding the changes in certain immune cells in the bone marrow, they can develop new treatments that could help patients whose cancers don’t respond well to traditional therapies. The study involves giving these immune cells special agents that may help them become more effective at attacking tumors.

To participate in this trial, individuals must be at least 18 years old and newly diagnosed with non-medullary thyroid or colon cancer, meaning they haven’t received any prior treatment. Participants should be planning to undergo surgery as part of their cancer treatment. Throughout the trial, participants can expect to receive close monitoring and care as researchers assess how these new approaches impact their immune response and overall health. It’s important to note that certain health conditions, such as being pregnant, having specific infections, or a history of other active cancers, may prevent someone from joining the study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • At least 18 years old and mentally competent
• • Newly diagnoses non-medullary thyroid carcinoma or colon carcinoma that is therapy naïve
• • Planned to receive conventional treatment for the malignancy by surgery
• Exclusion Criteria:
• • Mentally incompetent
• • Pregnant or breastfeeding
• • Known inflammation or infectious disease or an immunosuppressive status
• • Using medication interfering with the immune system
• • Reduced platelets counts or other conditions associated with an increased risk of bleeding
• • Severe comorbidities: other active malignancy (except for basal cell carcinoma and other in situ carcinomas)
• • Previous anti-cancer treatment, such as chemotherapy, radiotherapy or surgical removal or the primary tumor
• • Serious psychiatric pathology
• • A self-reported alcohol consumption of \>21 units per week