Medico-economic Evaluation of Management Strategies for Severe Epistaxis

Launched by UNIVERSITY HOSPITAL, TOULOUSE · Mar 7, 2022

Keywords

ClinConnect Summary

This clinical trial is studying the best treatment options for patients suffering from severe nosebleeds (epistaxis) that do not respond to standard treatments. The trial aims to compare two methods: surgical ligation and a procedure called supra-selective embolization. Both methods are currently considered to be equally effective, but there isn’t enough research to determine which one is better in terms of cost and efficiency. By examining these two approaches, the trial hopes to provide clearer guidance on how to manage this condition.

To participate in the trial, you need to be an adult over 18 years old who has had severe nosebleeds that lasted more than 48 hours despite treatment. You should also be part of a social security program and willing to accept random assignment to one of the treatment methods. However, if your nosebleed is due to trauma, cancer, or certain medical conditions, you may not be eligible. Participants will need to provide informed consent, meaning they understand the trial and agree to take part. This study is currently recruiting participants, so if you or someone you know is interested, it might be a good opportunity to help improve treatment options for severe epistaxis.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patient with severe epistaxis who failed treatment with double tamponade for more than 48 hours.
• • Patient over 18 years old
• • Affiliated patient or beneficiary of a social security scheme.
• • Patient accepting the principle of randomization
• • Free, informed and written consent, signed by the participant and the investigator (at the latest on the day of inclusion and before any examination required by the research).
• Exclusion Criteria:
• • Patient with epistaxis secondary to facial and/or surgical trauma.
• • Patient with epistaxis related to a malignant tumor cause
• • Patient with a history of ligation or embolization
• • Patient under legal protection and/or curatorship and/or guardianship.
• • Impossibility of giving the person informed information and ensuring the subject's compliance due to impaired physical and/or psychological health.
• • Patient participating in another research including an exclusion period still in progress
• • Pregnant or breastfeeding patient
• • For non randomized patient
• • Patient with a contraindication to general anesthesia: severe and/or decompensated cardiac/hepatic/renal insufficiency, ASA score 4
• • Severe hemostasis disorders that cannot benefit from correction.
• • History of transient and/or definitive stroke of the ischemic type
• • Atheromatous overload