The Organ Transplant Recipient HPV and Skin Cancer Study

Launched by MERETE HAEDERSDAL · Mar 9, 2022

Keywords

ClinConnect Summary

The Organ Transplant Recipient HPV and Skin Cancer Study is looking into how long-term treatment after receiving an organ transplant affects the risk of skin cancer and HPV-related cancers, such as cervical cancer. People who have had organ transplants need to take medications that weaken their immune system to prevent their body from rejecting the new organ. This makes them more vulnerable to certain types of cancer, and the study aims to gather important information about these risks. Researchers will study 1,800 participants, including 600 male and 600 female organ transplant recipients and 600 healthy controls, to better understand how immunosuppressive therapy impacts their health over time.

To be eligible for the study, organ transplant recipients must be at least 18 years old, have received a solid organ transplant (like a kidney, liver, lung, or heart), and have been on stable medication for at least three months. Participants will have their health monitored through clinical check-ups and data from national health registries. The goal is to improve cancer prevention and provide tailored screening recommendations based on individual risk factors. If you're considering participating, you'll be helping researchers learn how to keep organ transplant recipients safer from skin and HPV-related cancers.

Gender

ALL

Eligibility criteria

• Inclusion Criteria for OTRs:
• • Patients aged ≥18 years
• • Solid organ transplantation recipients, i.e. kidney-, liver-, lung-, and heart transplant recipients
• • Stable immunosuppressive treatment for ≥3 months
• • No signs of acute graft rejection
• • Patients who reside in Denmark
• • Informed written consent obtained
• Exclusion Criteria for OTRs:
• • Patients with concomitant bone marrow transplantation
• • Full hysterectomy
• Inclusion Criteria for Control group:
• • Able patients aged ≥18 years
• • No known immunosuppressive therapy or -condition
• • Patients who reside in Denmark
• • Informed written consent obtained
• Exclusion Criteria for Control group:
• • - Full hysterectomy