Use of Nasal Nitric Oxide Testing in Improving Primary Ciliary Dyskinesia Clinical Care

Launched by ARKANSAS CHILDREN'S HOSPITAL RESEARCH INSTITUTE · Mar 10, 2022

Keywords

ClinConnect Summary

This clinical trial is studying a condition called Primary Ciliary Dyskinesia (PCD), which affects the tiny hairs in the respiratory system that help clear mucus and keep the airways healthy. The researchers want to learn more about how testing the level of nitric oxide in the nose can help improve the diagnosis of PCD. They will compare these nitric oxide test results with other common tests to see how well they match up.

The trial is open to individuals aged 2 years and older who have either been diagnosed with PCD or are undergoing tests for it due to specific symptoms, such as persistent cough or frequent ear infections. Participants will be asked to provide consent and will undergo a nasal nitric oxide test. It’s important to note that some people may not qualify if they have had recent sinus surgery, are currently on antibiotics, or cannot complete the testing. This study seeks to enhance the understanding of PCD, which might lead to better care and outcomes for patients in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Individuals who are diagnosed with Primary Ciliary Dyskinesia OR
• • Individuals with abnormal PCD diagnostics (abnormal ciliary biopsy or PCD genetics) OR
• • Individuals with unexplained bronchiectasis OR
• * Individuals undergoing PCD diagnostic testing (ciliary biopsy, PCD genetic testing) or concern based on clinical symptoms (at least two of the following):
• • Neonatal respiratory distress
• • Organ laterality defects
• • Year-round cough starting in first year of life or bronchiectasis on chest CT
• • Year-round nasal congestion starting in first year of life or pansinusitis
• • Multiple ear infections in the first two years of life with sequelae (e.g. ear tubes, chronic effusion, abnormal audiological exam)
• • History of recurrent pneumonias (at least 2 in one year or more than 3 at any time)
• • Ability to provide consent for participation in study by the participants or guardian
• • Ability to perform the test
• • Age \>= 2 years of age
• Exclusion Criteria:
• • Individuals who are unable to understand the requirements of the study.
• • Individuals (or guardians) who are unwilling to provide consent.
• • Individuals who are unable to complete the testing
• • Recent history of sinus surgery (within four weeks) or bloody nose (within one week) of testing (they can be included at a later date)
• • Patients who are currently being treated (within one week) with antibiotics for sinusitis or respiratory symptoms (they can be included at a later date)
• • Age \<2 years of age