Oxytocin Maintenance Infusion in Labouring Women Undergoing Cesarean Delivery: an Up-down Sequential Allocation Study

Launched by SAMUEL LUNENFELD RESEARCH INSTITUTE, MOUNT SINAI HOSPITAL · Mar 11, 2022

Keywords

ClinConnect Summary

This clinical trial is studying how much oxytocin, a medication that helps the uterus contract after childbirth, is needed to effectively reduce blood loss during cesarean deliveries. The researchers aim to find the smallest amount of oxytocin that still works well for women who are in labor and require a cesarean section. Participants will receive a specific dose of oxytocin, and based on how well it helps their uterus contract, the dose for the next participant will be adjusted—either increased or decreased. This approach helps the team find the most effective dose for future patients.

To be eligible for this trial, participants must be women who are in labor and having a cesarean delivery while receiving a specific type of anesthesia. They should have already been given oxytocin for at least three hours during their labor. However, women who have allergies to oxytocin, certain health conditions like high blood pressure, or who cannot receive the type of anesthesia planned for the surgery will not be included. If a woman decides to participate, she can expect to be closely monitored during the trial to ensure her safety and the effectiveness of the medication. This study is currently recruiting participants.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • • All patients with induced or augmented labour undergoing cesarean delivery under neuraxial anesthesia (at least 3 hours of prior exposure to oxytocin during labour)
• Exclusion Criteria:
• • All patients who refuse to give written informed consent
• • All patients who declare allergy or hypersensitivity to oxytocin
• • A history of hypertension and/or severe cardiac disease(s)
• • All patients who have contraindications for neuraxial anesthesia
• • All patients who will be converted to general anesthesia intraoperatively
• • All patients with placenta previa and multiple gestation