Are Mast Cells Involved in Autoinflammatory Diseases

Launched by ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS · Mar 22, 2022

Keywords

ClinConnect Summary

This clinical trial is studying the role of mast cells, which are special immune cells in our bodies, in certain autoinflammatory diseases (AID). AID are conditions where the immune system behaves abnormally, leading to inflammation and other symptoms. The researchers want to understand how mast cells might be involved in these diseases, especially in patients with conditions like Familial Mediterranean Fever (FMF) and others that fall under the autoinflammatory umbrella. They will look at signs of mast cell activation by examining skin and digestive tissue samples from participants.

To participate in this study, you need to be over 18 years old and have a diagnosed autoinflammatory disease that is being managed at a specific hospital in France. Healthy adults of similar age and gender may also join as a comparison group. Participants will undergo evaluations, including clinical assessments and biopsies, to help researchers learn more about how mast cells contribute to these diseases. The trial is not yet recruiting participants, so there will be more information available in the future for anyone interested in taking part.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients \>18 years old with Auto-inflammatory diseases already followed up at the CeRéMAIA (french national reference center for autoinflamamtory diseases and AA amyloidosis) of Tenon hospital and included in the JIRcohorte
• • Healthy adult controls, age- and sex-matched with MAI patients, and controls with mastocytosis, an immuno-inflammatory disease.
• • Subject affiliated to or entitled to a social security scheme
• • Collection of the patient's or healthy control's non-opposition
• Exclusion Criteria:
• • Subjects unable to answer questions or express themselves
• • Subjects who do not speak French
• • Subject deprived of liberty or under legal protection.