Peri-operative Oral Pain Control Following Buccal Graft Urethroplasty
Launched by UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · Mar 24, 2022
Trial Information
Current as of August 25, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is studying how to manage pain after a specific type of surgery called buccal graft urethroplasty, which is performed to treat a condition known as urethral stricture in men. After this surgery, many patients experience significant pain in their mouths where tissue was taken for the graft. The trial aims to compare three different methods of numbing the area to see which one works best in reducing pain after the procedure, without causing additional problems.
To participate in this study, men aged 18 and older who are scheduled for this type of surgery can enroll, as long as they can provide consent. However, some individuals may not be eligible, including those with certain medical conditions, those who regularly take strong pain medications, or those with allergies to specific medications used in the study. Participants will be randomly assigned to receive one of the pain management techniques and will be monitored for their pain levels and any side effects after surgery. This trial is important because it aims to improve pain relief for patients and establish better practices for managing discomfort after this common surgical procedure.
Gender
MALE
Eligibility criteria
- Inclusion Criteria:
- • Men, age 18 or older
- • Undergoing anterior urethroplasty with buccal grafting
- • Able to consent
- Exclusion Criteria:
- • Taking chronic opiates for pain
- • Diagnosis of chronic pain
- • Prior buccal urethroplasty
- • Vulnerable population (e.g. prisoner)
- • Renal dysfunction or allergy preventing NSAID use
- • Liver dysfunction or allergy preventing Tylenol use
- • Medical allergy to local anesthetic
- • Medical allergy to Peridex/Magic Mouthwash
- • NYHA Class III/IV
- • Hematologic condition that excludes patient from surgery
- • Post-operative complication resulting in inpatient stay
- • Anesthetic complication
- • No buccal site surgical complication
About University Of California, San Francisco
The University of California, San Francisco (UCSF) is a leading academic institution renowned for its commitment to advancing healthcare through innovative research and clinical trials. With a focus on translating scientific discoveries into effective therapies, UCSF collaborates with a diverse array of stakeholders, including healthcare professionals, industry partners, and patient communities. The university's research programs emphasize interdisciplinary approaches and leverage cutting-edge technology to address complex medical challenges. As a sponsor of clinical trials, UCSF is dedicated to maintaining the highest standards of ethical conduct and scientific rigor, ensuring the safety and well-being of participants while contributing to the broader medical knowledge base.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
San Francisco, California, United States
Washington, District Of Columbia, United States
Patients applied
Trial Officials
Lindsay Hampson, MD
Principal Investigator
University of California, San Francisco
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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