Translational Immunodiagnostics in Stroke (TrImS)

Launched by THE UNIVERSITY OF HONG KONG · Mar 18, 2022

Keywords

ClinConnect Summary

The Translational Immunodiagnostics in Stroke (TrImS) trial is studying ways to detect and diagnose strokes more quickly and accurately. Researchers are looking for specific markers in the blood and saliva of adults who show signs of having a stroke within 24 hours of their symptoms starting. By identifying these markers, they hope to improve how strokes are diagnosed and understood, which can lead to better treatment and outcomes for patients.

To participate in this trial, you need to be at least 18 years old and suspected of having a stroke based on certain tests. The study is currently recruiting participants, including those who have experienced an acute stroke or a transient ischemic attack (a temporary stroke-like event). If you decide to join, you will provide samples of your blood and saliva, which will help researchers develop and validate new tools for early stroke detection. It's important to note that patients with specific recent medical conditions or treatments may also be included in the study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• * Patients eligible for enrolment include:
• • Adults ≥18 years of age.
• • Suspected acute stroke. Defined as either FAST-positive, or LAPSS-positive or ROSIER\>0
• • Within 24 hours of symptom onset.
• • Informed consent.
• * Control subjects will be drawn from two groups:
• • Non-neurologic patients who are matched with TIA and stroke cases (AIS, HS) for age, race, gender and smoking plus one or more of the following vascular risk factors: diabetes, hypertension, atrial fibrillation, hyperlipidaemia.
• • Relatives or accompanying friends.
• • Note that we will include and collect samples from the following cases if they present as suspected stroke and are recruited \<24 hours from symptom onset.
• • Any central nervous system infection, i.e. meningitis or encephalitis in the past 30 days
• • Any form of head trauma, stroke or intracranial haemorrhage in the past 30 days
• • Known primary or metastatic cancer involving the brain
• • Active cancer is defined as a diagnosis of cancer, within 6 months before enrollment, any treatment for cancer within the previous 6 months, or recurrent or metastatic cancer.
• • Autoimmune diseases: such as lupus, rheumatoid arthritis, Crohn's disease, ulcerative colitis
• • Active infectious diseases (e.g. HIV/AIDS, hepatitis C)
• • Major surgery within three months prior to the index event
• Exclusion Criteria:
• • Clear onset of acute symptoms \>24 hours.