Topical Sevoflurane for Treatment of Chronic Leg Ulcers

Launched by CHARLES UNIVERSITY, CZECH REPUBLIC · Mar 21, 2022

Keywords

ClinConnect Summary

This clinical trial is studying a new treatment for painful leg ulcers that haven't healed. The researchers want to see if applying a substance called sevoflurane directly to the ulcer can help it heal better than a standard rinse solution used in regular treatment. Participants in the trial will be divided into two groups: one will receive the sevoflurane treatment, while the other will receive the standard rinse. The trial lasts for five days, but it may end sooner if the ulcer heals quickly.

To join the study, participants should be between the ages of 65 and 74 and have a painful leg ulcer that scores higher than 4 on a pain scale from 0 to 10. Unfortunately, people who are allergic to sevoflurane or who have difficulty understanding the pain questionnaire cannot participate. Throughout the trial, researchers will monitor the participants for pain levels, signs of infection, and changes in the ulcer's appearance and size. This study aims to find a potentially more effective treatment for painful and persistent leg ulcers.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients with painful (pain intensity on the numerical scale NRS 0-10 is NRS\>4) non- healing tibial venous ulcers
• Exclusion Criteria:
• • Allergy to sevoflurane
• • Inability to understand the pain-intensity questionnaire