Stand UP to Rheumatoid Arthritis (SUPRA)

Launched by MARIE HUDSON, MD · Mar 22, 2022

Keywords

ClinConnect Summary

The Stand UP to Rheumatoid Arthritis (SUPRA) trial is studying how to find the best treatments for people with rheumatoid arthritis (RA), a painful condition that often affects younger women. The goal is to personalize medicine, meaning they want to match the right medication to the right patient at the right time. This study is currently recruiting participants who are at least 18 years old and have been diagnosed with RA. To be eligible, participants should have already tried certain standard treatments that didn’t work for them and need to explore new options.

If you join the trial, you can expect to work closely with researchers who will assess your specific situation and treatment needs. The study is open to all genders, but there are some important criteria to consider. For example, participants should not have had certain previous treatments or have specific health issues that might complicate their participation. This research is crucial for helping doctors provide better, more tailored treatments for individuals living with rheumatoid arthritis.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥ 18 years;
• • Arthritis that fulfills the 2010 ACR/EULAR classification criteria for RA;
• • Failure to standard conventional synthetic DMARDs and eligible for second-line b/tsDMARDs (Sub-study 1) or failure to at least one TNF inhibitor and eligible for third-line b/tsDMARDs (Sub-study 2).
• Exclusion Criteria:
• • Prior b/tsDMARDs for Sub-study 1 or prior b/tsDMARDs other than TNF inhibitors for Sub-study 2;
• • Contraindication to b/tsDMARD therapy, such as active infection or untreated latent TB, current malignancy, severe organ dysfunction, history of VTE (unless anticoagulated), high risk of cardiovascular disease, pregnancy/lactation;
• • Overlap with another inflammatory disease requiring specific immunosuppressive therapy, such as lupus nephritis;
• • Unable to provide consent or complete forms (alone or with assistance) in English or French