Pediatric Liver Transplantation-Liver Fibrosis Evaluation by Using Fibrosis Panel

Launched by RENJI HOSPITAL · Apr 1, 2022

Keywords

ClinConnect Summary

This clinical trial is studying how certain tests can help monitor liver health in children who have received a liver transplant. While liver transplants in children are generally very successful, there are concerns about potential long-term issues, such as liver damage or inflammation that can occur after the transplant. The researchers want to see if specific markers in the blood (called the Fibrosis Panel) can predict these problems and help ensure that children can lead healthy lives after their transplant.

To participate in the study, children between 8 weeks and 18 years old who have received their first liver transplant are eligible. Their parents or guardians will need to give permission for them to join the study. If a child is pregnant, has certain infections, or has had multiple organ transplants, they won’t be able to participate. Those who join the study will undergo blood tests to check their liver function and help doctors understand the long-term effects of liver transplantation in children. This research is important because it aims to improve care and outcomes for young transplant recipients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Male or female participant must be between 8 weeks and 18 years of age.
• • Participant is a recipient of a first liver allograft from cadaveric or living donors.
• • Participant is a single-organ recipient (liver only).
• • Participants' parent/guardian is capable of understanding the purposes and risks of the study and must sign an informed consent for the study.
• Exclusion Criteria:
• • Participants older than 18 years of age
• • Pregnant or breastfeeding
• • Active systemic infections
• • Receiving any form of solid organ retransplantation
• • Multiorgan transplantation
• • Multi organ failure
• • Congenital sufferers from heart, lung, kidney, nervous system or blood disease
• • Refused to participate the study