Aortic Compression Trial to Reduce Blood Loss at Cesarean Section
Launched by KAROLINSKA INSTITUTET · Mar 28, 2022
Trial Information
Current as of June 26, 2025
Enrolling by invitation
Keywords
ClinConnect Summary
The Aortic Compression Trial (ACT) - A randomized controlled trial to reduce blood loss in cesarean delivery
PURPOSE AND AIMS The purpose is to reduce the prevalence of severe postpartum hemorrhage (PPH), causing maternal mortality and morbidity worldwide. The aim is to investigate if routine manual external aortic compression (EAC) in cesarean delivery (CD) is an effective and safe measure to prevent severe PPH, in a multicenter randomized controlled superiority trial.
SURVEY OF THE FIELD Severe PPH is defined as blood loss \>1000 ml at childbirth. Severe PPH is associated with 25% of ma...
Gender
FEMALE
Eligibility criteria
- Inclusion Criteria:
- • Planned cesarean delivery
- • Live fetus/fetuses if multiple pregnancy
- • Gestational week 34+0 or more
- Exclusion Criteria:
- • Preoperative B-Hemoglobin \<100 g/l
- • Planned hysterectomy in the same procedure as the planned cesarean delivery
- • Other condition as deemed by attending surgeon.
About Karolinska Institutet
Karolinska Institutet is a renowned medical university located in Sweden, recognized for its commitment to advancing healthcare through innovative research and education. As a leading sponsor of clinical trials, the institution focuses on translating scientific discoveries into effective treatments and therapies, emphasizing patient-centered approaches. With a strong emphasis on collaboration and interdisciplinary research, Karolinska Institutet plays a pivotal role in addressing global health challenges and improving patient outcomes, leveraging its extensive network of experts and state-of-the-art facilities to drive clinical advancements.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Stockholm, , Sweden
Patients applied
Trial Officials
Sophia Brismar Wendel, MD, PhD
Principal Investigator
Danderyd Hospital Karolinska Institutet, Sweden
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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