Evaluating the Diagnostic and Predictive Value of Non-invasive Tests (NITs) on the Progression of Chronic Liver Disease.

Launched by JOHANNES GUTENBERG UNIVERSITY MAINZ · Mar 28, 2022

Keywords

ClinConnect Summary

This clinical trial is looking at how non-invasive tests (NITs) can help doctors understand and predict the progression of chronic liver disease. The goal is to see if these tests can accurately indicate the stage of the disease and help forecast outcomes for patients who either have suspected liver issues or have already been diagnosed with cirrhosis, which is a serious condition where the liver is damaged.

To be eligible for this trial, participants must be at least 18 years old and have suspected chronic liver disease, which can be determined by prior liver biopsies, current medical imaging, or other clinical signs. Unfortunately, individuals who are pregnant, have certain cancers, or are expected to live less than five years will not be able to participate. If you join the study, you can expect to undergo these non-invasive tests, which aim to provide valuable information about your liver health without the need for more invasive procedures. This research could ultimately help improve how chronic liver disease is diagnosed and managed in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age ≥18 years
• 2. Clinically suspected chronic liver disease based on any of:
• • 1. Patient with historical liver biopsy providing histological evidence of any liver disease or,
• • 2. Patient undergoing liver biopsy for suspected chronic liver disease with biochemical and/or radiological findings consistent with liver disease or,
• • 3. Patient with clinical and radiological evidence of cirrhosis (in absence of an alternative aetiology)
• • 4. Patients with metabolic risk factors predisposing to CLD
• Exclusion Criteria:
• • 1. Refusal or inability (lack of capacity) to give informed consent.
• • 2. Age \< 18 years
• • 3. Pregnancy
• • 4. An active malignancy.
• • 5. Life expectation of \< 5 years.
• • 6. Patients not meeting inclusion criteria or judged by the investigator to be unsuitable for inclusion in the study.