Phase 2/3 Adaptive Study of VX-147 in Adult and Pediatric Participants With APOL1- Mediated Proteinuric Kidney Disease
Launched by VERTEX PHARMACEUTICALS INCORPORATED · Mar 28, 2022
Trial Information
Current as of June 27, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is studying a new treatment called VX-147 for patients with a specific type of kidney disease known as APOL1-mediated proteinuric kidney disease. This condition can lead to protein in the urine, which indicates that the kidneys are not working properly. The trial aims to find out if VX-147 is effective and safe for both adults and children who have this type of kidney disease.
To participate in the trial, individuals must have a certain genetic makeup (APOL1 genotype) and be diagnosed with proteinuric kidney disease. However, those who have had a solid organ or bone marrow transplant, have uncontrolled high blood pressure, or a history of diabetes may not be eligible. Participants can expect to receive the study drug and will be closely monitored throughout the trial to ensure their safety and to see how well the treatment works. This study is currently recruiting participants, and it is open to people of all genders between the ages of 1 and 65 years.
Gender
ALL
Eligibility criteria
- Key Inclusion Criteria:
- • APOL1 genotype of G1/G1, G2/G2, or G1/G2
- • Proteinuric kidney disease
- Key Exclusion Criteria:
- • Solid organ or bone marrow transplant
- • Uncontrolled hypertension
- • History of diabetes mellitus
- • Known underlying cause of kidney disease including but not limited to sickle cell disease
- • Other protocol defined Inclusion/Exclusion criteria apply.
About Vertex Pharmaceuticals Incorporated
Vertex Pharmaceuticals Incorporated is a global biotechnology company dedicated to the innovation and development of transformative therapies for serious diseases, particularly those with significant unmet medical needs. Founded in 1989 and headquartered in Boston, Massachusetts, Vertex specializes in the research and commercialization of treatments for cystic fibrosis and other genetic disorders. Leveraging cutting-edge science and a commitment to patient-centric solutions, Vertex collaborates with healthcare professionals and researchers to advance clinical trials and bring groundbreaking therapies to market, aiming to improve the lives of patients worldwide.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Chicago, Illinois, United States
Kansas City, Kansas, United States
Milwaukee, Wisconsin, United States
Charleston, South Carolina, United States
Chicago, Illinois, United States
Bronx, New York, United States
Iowa City, Iowa, United States
London, , United Kingdom
Boston, Massachusetts, United States
New Orleans, Louisiana, United States
Detroit, Michigan, United States
Los Angeles, California, United States
Little Rock, Arkansas, United States
Boston, Massachusetts, United States
Hackensack, New Jersey, United States
Philadelphia, Pennsylvania, United States
Baltimore, Maryland, United States
Barcelona, , Spain
Indianapolis, Indiana, United States
Boston, Massachusetts, United States
Birmingham, Alabama, United States
Cleveland, Ohio, United States
Seattle, Washington, United States
Gainesville, Florida, United States
Richmond, Virginia, United States
Baltimore, Maryland, United States
Pittsburgh, Pennsylvania, United States
Fort Worth, Texas, United States
Cincinnati, Ohio, United States
Dallas, Texas, United States
Philadelphia, Pennsylvania, United States
Brooklyn, New York, United States
Lubbock, Texas, United States
New York, New York, United States
New Haven, Connecticut, United States
Nashville, Tennessee, United States
Birmingham, Alabama, United States
San Francisco, California, United States
Hines, Illinois, United States
Barcelona, , Spain
Jackson, Mississippi, United States
New York, New York, United States
São Paulo, , Brazil
Ibadan, , Nigeria
Columbus, Ohio, United States
Seattle, Washington, United States
Amsterdam, , Netherlands
Albuquerque, New Mexico, United States
Columbus, Mississippi, United States
Olive Branch, Mississippi, United States
Brandon, Florida, United States
Oxon Hill, Maryland, United States
Leuven, , Belgium
Torrance, California, United States
Manchester, , United Kingdom
Sao Paulo, , Brazil
Seville, , Spain
Houston, Texas, United States
Middlebury, Connecticut, United States
Lansing, Michigan, United States
Cleveland, Ohio, United States
Huntsville, Alabama, United States
Madrid, , Spain
Nottingham, , United Kingdom
Chattanooga, Tennessee, United States
Porto Alegre, , Brazil
Charleston, South Carolina, United States
Bronx, New York, United States
Barcelona, , Spain
Paris, , France
London, , United Kingdom
Metairie, Louisiana, United States
Tupelo, Mississippi, United States
Chapel Hill, North Carolina, United States
Brooklyn, New York, United States
Columbia, South Carolina, United States
Farmington Hills, Michigan, United States
Baton Rouge, Louisiana, United States
Los Angeles, California, United States
Newark, New Jersey, United States
Rio De Janeiro, , Brazil
Granada Hills, California, United States
Lauderdale Lakes, Florida, United States
Atlanta, Georgia, United States
Los Angeles, California, United States
Hialeah, Florida, United States
Washington, District Of Columbia, United States
Arlington, Texas, United States
Gainesville, Florida, United States
Kumasi, , Ghana
Albuquerque, New Mexico, United States
Roseville, Michigan, United States
Sacramento, California, United States
Créteil, , France
Bradenton, Florida, United States
São José Do Rio Preto, , Brazil
Cali, , Colombia
Laurelton, New York, United States
London, , United Kingdom
Saint Louis, Missouri, United States
Springfield, Massachusetts, United States
San Antonio, Texas, United States
Huntsville, Alabama, United States
Medellín, , Colombia
Miami, Florida, United States
Manchester, , United Kingdom
Dallas, Texas, United States
Enugu, , Nigeria
Dallas, Texas, United States
New Orleans, Louisiana, United States
Córdoba, , Spain
Leuven, , Belgium
Lawrenceville, Georgia, United States
Minneapolis, Minnesota, United States
New Orleans, Louisiana, United States
Columbus, Georgia, United States
Webster, Texas, United States
London, , United Kingdom
Belo Horizonte, , Brazil
Camden, New Jersey, United States
Ikeja, , Nigeria
Wauwatosa, Wisconsin, United States
Tyrone, Georgia, United States
Miami, Florida, United States
Bronx, New York, United States
Flint, Michigan, United States
Charlotte, North Carolina, United States
Decatur, Georgia, United States
San Juan, , Puerto Rico
Nashville, Tennessee, United States
Natchitoches, Louisiana, United States
New York, New York, United States
Shreveport, Louisiana, United States
Tampa, Florida, United States
Houston, Texas, United States
East Providence, Rhode Island, United States
Brunswick, Georgia, United States
Birmingham, Alabama, United States
Washington, District Of Columbia, United States
Atlanta, Georgia, United States
Las Vegas, Nevada, United States
Paris, , France
Paris, , France
Paris, , France
Leicester, , United Kingdom
Southwark, , United Kingdom
Union City, Georgia, United States
Delray Beach, Florida, United States
Miami, Florida, United States
Temple Terrace, Florida, United States
Granada Hills, California, United States
Lisboa, , Portugal
Orange, California, United States
Orlando, Florida, United States
Bronx, New York, United States
Victorville, California, United States
Edina, Minnesota, United States
Little Rock, Arkansas, United States
Mesa, Arizona, United States
Coral Gables, Florida, United States
Hollywood, Florida, United States
Atlanta, Georgia, United States
Roseville, Minnesota, United States
Flushing, New York, United States
Laurelton, New York, United States
Greenville, North Carolina, United States
Jacksonville, North Carolina, United States
Kinston, North Carolina, United States
New Bern, North Carolina, United States
Wilmington, North Carolina, United States
Winston Salem, North Carolina, United States
Virginia Beach, Virginia, United States
Dallas, Texas, United States
Loures, , Portugal
Phoenix, Arizona, United States
Fresno, California, United States
Cape Coral, Florida, United States
Shreveport, Louisiana, United States
Chapel Hill, North Carolina, United States
Miami Springs, Florida, United States
Nashville, Tennessee, United States
London, , United Kingdom
Spartanburg, South Carolina, United States
Bloomfield, Connecticut, United States
Coral Springs, Florida, United States
Sanford, Florida, United States
Las Vegas, Nevada, United States
Bronx, New York, United States
El Paso, Texas, United States
Houston, Texas, United States
Shenandoah, Texas, United States
Norfolk, Virginia, United States
Montreal, , Canada
Grenoble, , France
Mishawaka, Indiana, United States
Cary, North Carolina, United States
San Antonio, Texas, United States
Grenoble, , France
Le Kremlin Bicêtre, , France
Saint Ouen, , France
Santo Andre, , Brazil
Savannah, Georgia, United States
Norfolk, Virginia, United States
Marseille, , France
Los Angeles, California, United States
New York, New York, United States
Limoges, , France
Mansfield, Texas, United States
Houston, Texas, United States
Toulouse, , France
Carshalton, , United Kingdom
Atlanta, Georgia, United States
The Woodlands, Texas, United States
London, , United Kingdom
Bay Pines, Florida, United States
Woluwe Saint Lambert, Brussels, Belgium
Phoenix, Arizona, United States
Augusta, Georgia, United States
Philadelphia, Pennsylvania, United States
Dallas, Texas, United States
Columbus, Georgia, United States
Grenada, Mississippi, United States
Houston, Texas, United States
Hallandale Beach, Florida, United States
Minas Gerais, , Brazil
São Paulo, , Brazil
Amadora, , Portugal
Toronto, , Canada
West Springfield, Massachusetts, United States
Great Neck, New York, United States
Atlanta, Georgia, United States
Saint Louis, Missouri, United States
New York, New York, United States
Ribeirão Preto, , Brazil
Birmingham, , United Kingdom
Fayetteville, Georgia, United States
Charlottesville, Virginia, United States
Curitiba, , Brazil
Curitiba, , Brazil
Juiz De Fora, , Brazil
Juiz De Fora, , Brazil
Rio De Janeiro, , Brazil
London, , United Kingdom
Goiania, , Brazil
Salvador, , Brazil
Silver Spring, Maryland, United States
Coral Gables, Florida, United States
Annapolis, Maryland, United States
Dallas, Texas, United States
Dallas, Texas, United States
Porto Alegre, , Brazil
Rio De Janeiro, , Brazil
Roxbury, Massachusetts, United States
Overland Park, Kansas, United States
Arlington, Texas, United States
Richmond, Virginia, United States
Fortaleza, , Brazil
Juiz De Fora, , Brazil
Ribeirao Preto, , Brazil
Brandon, Florida, United States
Evergreen Park, Illinois, United States
Palos Hills, Illinois, United States
Ann Arbor, Michigan, United States
Dallas, Texas, United States
East Point, Georgia, United States
Saint Clair Shores, Michigan, United States
Saint Louis, Missouri, United States
Las Vegas, Nevada, United States
Durham, North Carolina, United States
Salvador, , Brazil
Atlántico, , Colombia
New Orleans, Louisiana, United States
Gaithersburg, Maryland, United States
Accra, , Ghana
Birmingham, , United Kingdom
Atlanta, Georgia, United States
Cartagena, , Colombia
Rio Piedras, , Puerto Rico
Tampa, Florida, United States
Orlando, Florida, United States
New York, New York, United States
Bogota, , Colombia
Lewisville, Texas, United States
Fortaleza, , Brazil
Saint Louis, Missouri, United States
Norfolk, Virginia, United States
Norfolk, Virginia, United States
Atlántico, , Colombia
Fayette, Mississippi, United States
Lisboa, , Portugal
Ridgeland, Mississippi, United States
Sanford, Florida, United States
West Monroe, Louisiana, United States
Fairhope, Alabama, United States
Cantonments, , Ghana
Vestavia Hills, Alabama, United States
Chicago, Illinois, United States
Montgomery, Alabama, United States
Charleston, South Carolina, United States
Memphis, Tennessee, United States
Campinas, , Brazil
Marilia, , Brazil
Guadeloupe, , France
Alabaster, Alabama, United States
College Park, Georgia, United States
Fort Wayne, Indiana, United States
Brooklyn, New York, United States
Cincinnati, Ohio, United States
Cleveland, Ohio, United States
Basildon, , United Kingdom
Recife, , Brazil
Nottingham, Maryland, United States
Edina, Minnesota, United States
Dallas, Texas, United States
Aracaju, , Brazil
Meireles, , Brazil
Sao Paulo, , Brazil
Agodi, Ibadan, , Nigeria
Botucatu, , Brazil
Botucatu, , Brazil
Yaba, , Nigeria
Chicago, Illinois, United States
New York, New York, United States
Salvador, , Brazil
Medellin, , Colombia
Nottingham, , United Kingdom
Jacksonville, Florida, United States
Acworth, Georgia, United States
Douglasville, Georgia, United States
Memphis, Tennessee, United States
Dallas, Texas, United States
Ibague, , Colombia
Idi Araba, , Nigeria
Birmingham, , United Kingdom
Manchester, , United Kingdom
Bellshill, , United Kingdom
Orlando, Florida, United States
Lewisville, Texas, United States
Birmingham, Alabama, United States
Hamilton, New Jersey, United States
Mesa, Arizona, United States
Augusta, Georgia, United States
Bronx, New York, United States
Houston, Texas, United States
Agodi, , Nigeria
Atlanta, Georgia, United States
Augusta, Georgia, United States
Miami, Florida, United States
Orlando, Florida, United States
Chicago, Illinois, United States
Baltimore, Maryland, United States
Wauwatosa, Wisconsin, United States
Fortaleza, , Brazil
Pointe à Pitre Cedex, , France
Mayaguez, , Puerto Rico
Orlando, Florida, United States
Saint Louis, Missouri, United States
Orlando, Florida, United States
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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