Diagnosis and Bacterial Identification of Periprosthetic Joint Infection With Microbial-ID

Launched by UMC UTRECHT · Apr 1, 2022

Keywords

ClinConnect Summary

In the diagnosis of periprosthetic joint infection (PJI) there is no golden standard test. Multiple definitions for the diagnosis of PJI exist, such as the European Bone and Joint Infection Society (EBJIS)1, Musculoskeletal Infection Society (MSIS)2, and the Infectious Diseases Society of America (IDSA)3. One of the criteria that defines PJI is that there are at least two positive periprosthetic cultures with phenotypically identical organisms. Although these two positive bacterial cultures can certainly be considered proof of PJI, many other criteria are also used, such as a sinus tract, w...

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Eligibility criteria

• Inclusion Criteria:
• • Patient has complaints (pain, stiffness) about the prosthetic joint And has clinical features for joint infection at physical examination (swelling, redness, warm, sinus tract) AND has an elevated serum CRP (\>10 mg/L)
• • Patient is scheduled for a puncture AND/OR surgery, with harvesting of synovial fluid
• • Patient ≥ 18 years of age
• • Patient is competent, able, and willing to provide written informed consent
• Exclusion Criteria:
• • Treatment with antibiotics ≤2 weeks prior to puncture and/or surgery;
• • Other obvious reason(s) for implant dysfunction, such as: fracture, an implant breakage, a malposition, and/or a tumour.