The Bioavailability and Effect on Pouch pH of Esomeprazole After Gastric Bypass

Launched by PROF URS ZINGG · Apr 6, 2022

Keywords

ClinConnect Summary

This clinical trial is studying how well a medication called Esomeprazole works for people who have had gastric bypass surgery. Specifically, it looks at how the medicine affects the amount of acid produced in the stomach pouch, which is important for managing conditions like obesity and gastric reflux. Participants will receive Esomeprazole either in tablet form or mixed in water, and the researchers will measure the acidity in the stomach and the levels of the medicine in the blood.

To be eligible for this study, participants should have undergone a specific type of gastric bypass surgery at least a year ago, have been taking proton pump inhibitors (which help reduce stomach acid) for six months after their surgery, and not have any recent symptoms or ulcers. They should also be able to follow the study procedures and not have any serious health issues that could interfere. Those who join the trial can expect to help researchers learn more about how Esomeprazole works in different forms, which could lead to better treatment options for people with similar digestive issues.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Proximal Roux-en-Y gastric bypass with linear stapled anastomosis 12 months prior to the study investigation
• • Routine administration of proton pump inhibitors for 6 months postoperatively
• • No intake of proton pump inhibitors at least 4 weeks prior to study investigation
• • No marginal ulcers in upper endoscopy prior to placement of wireless BRAVO™ pH monitoring capsule
• • No symptoms related to gastro-esophageal reflux or marginal ulcers (i.e. epigastric pain, retrosternal burning, regurgitation)
• • Informed consent as documented by signature
• Exclusion Criteria:
• • Known intolerance or allergy for Esomeprazol
• • Contraindication for upper endoscopy
• • Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant
• • Women who are pregnant or breast feeding Major hepatic dysfunction