Pragmatic Randomised Trial of the ESC 0/1 Versus 0/3 Hour Troponin Pathway

Launched by LIVERPOOL UNIVERSITY HOSPITALS NHS FOUNDATION TRUST · Apr 7, 2022

Keywords

ClinConnect Summary

This clinical trial is exploring a new approach to testing for heart problems, specifically looking at how quickly we can measure troponin levels in patients with chest pain. Troponin is a protein that can indicate heart injury, and the trial will compare two timing methods: the current 0-3 hour system versus a newer 0-1 hour method. The goal is to see if the quicker method is safe and effective for use in everyday clinical settings.

To participate, individuals should be at least 18 years old and have recently experienced chest pain that raises concern for heart issues. The trial is currently recruiting patients who seek care within 12 hours of their chest pain starting. However, those with certain conditions, like a heart attack shown on an initial heart test or trauma, are not eligible. Participants will receive care according to one of the two troponin testing methods, helping researchers understand which approach works best in practice.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Chest pain with moderate or high suspicion chest pain (see chest pain evaluation chart at end) or any patient the clinician deems suspicious for myocardial ischaemia thus requesting a troponin sample (between daytime hours 0800hrs to 1800hrs)
• • Presentation \<12 hours since onset of chest pain (or unknown duration)
• • Age \>18 years of age
• Exclusion Criteria:
• • ST elevation myocardial infarction (STEMI) infarct on the presenting electrocardiogram (ECG)
• • Symptoms considered definitely non-cardiac
• • Trauma
• • Pregnancy
• • Comorbid conditions requiring hospital admission
• • Coronary artery bypass graft surgery (CABG) \<1 month
• • coexistent clinical conditions likely to preclude follow-up.