Maintaining Immune and Mitochondrial Functions in Old Adults With SAfe Nutrition.

Launched by PATRIZIA D'AMELIO · Apr 5, 2022

Keywords

ClinConnect Summary

The clinical trial titled "Maintaining Immune and Mitochondrial Functions in Old Adults with Safe Nutrition" aims to explore how nutritional supplements can help older adults, especially those experiencing malnutrition and muscle loss (sarcopenia). As people age, their bodies can become more inflamed and less able to fight off illnesses, which can be linked to poor nutrition. This study will focus on how a personalized dietary approach might improve the function of cells responsible for energy production and support the immune system, ultimately enhancing overall health in older individuals.

To be eligible for this trial, participants must be at least 75 years old, diagnosed with malnutrition, and ready to follow the nutritional plan provided. They should also be entering a rehabilitation program and able to understand the study's requirements. However, individuals with certain serious health conditions, such as advanced heart failure or liver disease, will not be able to participate. Those who join the study can expect to receive nutritional supplements tailored to their needs, with the hope of improving their health and well-being. The trial is not yet recruiting participants, but it represents a promising effort to help older adults maintain their health through better nutrition.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥75 years
• • Patients entering a rehabilitation program
• • Diagnosis of malnutrition defined by a MNA-SF (mini-nutritional assessment short form) score below 11 points.
• • Commitment to accept the nutritional supplement proposed, willing and able to give written informed consent
• • Ability to understand and comply with the requirements of the study
• Exclusion Criteria:
• • Presence of malignancy,
• • Life expectancy of less than two months calculated by Multidimensional Prognostic Index (MPI ),
• • Congestive heart failure (NYHA IV),
• • Chronic renal disease (creatinine clearance \<40 ml/min calculated by cockroft),
• • Liver cirrhosis (Child B-C),
• • Tube/percutaneous endoscopic gastrostomy feeding or parenteral nutrition,
• • Severe dysphagia,
• • Mini-Mental State Examination (MMSE)≤18 and MNA\>11 points. MMSE ≥ 18 identifies patients with mild form of cognitive impairment; those patients generally do not have problems in swallowing and are able to take drugs.
• • Severe anaemia (Hb\<10 g/l) or leukopenia (\<2G/l).