Urinary Continence of Female POPRC and OIN

Launched by SUN YAT-SEN MEMORIAL HOSPITAL OF SUN YAT-SEN UNIVERSITY · Apr 12, 2022

Keywords

ClinConnect Summary

This clinical trial is designed to compare two different surgical approaches for women with early-stage bladder cancer. The researchers want to see how well a new method called pelvic-organ preserving radical cystectomy (POPRC), along with an orthotopic ileal neobladder (a type of bladder reconstruction using a piece of the intestine), works in maintaining urinary control and ensuring long-term cancer outcomes compared to the standard radical cystectomy (SRC) that also uses an orthotopic ileal neobladder.

To participate in this study, women aged 55 to 75 who have been diagnosed with early-stage bladder cancer (specifically, cancer that has not spread beyond the bladder) may be eligible. Participants should have good overall health, normal kidney function, and be willing to sign consent forms to join the trial. If you’re selected, you can expect to receive information about the procedures, and you will be closely monitored throughout the study to assess how well the surgeries work for bladder control and cancer treatment. It’s important to note that certain health conditions and previous cancer treatments may exclude some women from participating.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • 1. Female patients aged between 55-75.
• • 2. Patients those who are diagnosed with organ-confined urothelial carcinoma（\<pT3）
• • 3. Patients those who are capable for radical cystectomy with orthotopic ileal neobladder.
• • 4. ECOG score between 0-2;
• • 5. Normal renal function;
• • 6. Patients those who volunteer to participate in this study and sign the informed consents.
• • 7. Patients those who are able to cooperate in the study.
• Exclusion Criteria:
• • 1. Absence of tumour in bladder neck or urethra;
• • 2. Patients thsoe who are diagnosed distant metastasis before surgery.
• • 3. Previous history of malignancy of pelvic organs or surgical resection of pelvic organs;
• • 4. Patients those who are diagnosed with other malignancies.;
• • 5. Patients those who had received pelvic radiotherapy or major pelvic operation.
• • 6. Pregnancy status;
• • 7. Any other conditions that the researcher considers to be excluded from this study