Testing Home-based Exercise Strategies in Underserved Minority Cancer Patients Undergoing Chemotherapy: the THRIVE Study

Launched by DANA-FARBER CANCER INSTITUTE · Apr 11, 2022

Keywords

ClinConnect Summary

The THRIVE Study is a research trial aimed at helping Black and Hispanic patients with breast, colorectal, or prostate cancer who are starting chemotherapy. The study will look at whether a 16-week exercise program done at home can help these patients become more active. Participants will be divided into three groups: one group will do supervised aerobic and resistance exercises through Zoom, another group will do the exercise unsupervised at home, and the third group will focus on gentle stretching exercises.

To join the study, participants need to be over 18 years old, newly diagnosed with stage I-III cancer, and starting chemotherapy within the next four weeks. They should also be overweight or obese and currently not exercising much. The study will require occasional travel to the Dana-Farber Cancer Institute for check-ins. This trial hopes to find out if these home-based exercise strategies can improve health and well-being during cancer treatment.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Over 18 years old; children under the age of 18 will be excluded due to rarity of disease
• • Newly diagnosed with stage I-III breast, colorectal or prostate cancer
• • Self-identify as Hispanic or Black
• • Are within 4 weeks of initiating chemotherapy
• • Overweight or obese (BMI \>25kg/m2 or body fat percent \>30)
• • Physician's clearance to participate in moderate-vigorous intensity exercise
• • Speak English or Spanish
• • Engaging in less than 90 minutes of moderate-or-vigorous physical activity per week
• • Willing to travel to Dana-Farber Cancer Institute for necessary data collection
• • Ability to understand and the willingness to sign a written informed consent document.
• Exclusion Criteria:
• • Pre-existing musculoskeletal or cardiorespiratory conditions
• • Patients should not have any uncontrolled illness including ongoing or active infection, uncontrolled diabetes, hypertension, or thyroid disease
• • Patients with other active malignancies
• • Patients with metastatic disease
• • Participate in more than 90 minutes of structured exercise/week
• • Unable to travel to Dana-Farber Cancer Institute for necessary data collection
• • Subjects, who in the opinion of the investigator, may not be able to comply with the safety monitoring requirements of the study.