Exercise to Enhance Cardiovascular Health Among Black Prostate Cancer Patients With Androgen Deprivation Therapy

Launched by DANA-FARBER CANCER INSTITUTE · Apr 11, 2022

Keywords

ClinConnect Summary

This clinical trial is exploring whether a special 16-week exercise program can help improve heart health in Black men with prostate cancer who are receiving a treatment called androgen deprivation therapy (ADT). The program includes aerobic and resistance exercises, which means it focuses on both improving heart fitness and building strength. Researchers want to see if this exercise program can lead to better physical fitness, body composition, and overall quality of life, as well as reducing cancer symptoms and boosting self-esteem.

To participate in this study, you need to be a Black man over 18 years old who has been diagnosed with localized or metastatic prostate cancer and has been on ADT for at least a month. You should be cleared by a doctor to exercise and currently do less than 60 minutes of structured exercise each week. Participants will be randomly placed into one of two groups: one that engages in the exercise program and one that receives usual care. If you join the study, you will need to travel to the Dana-Farber Cancer Institute for data collection. This trial is actively recruiting participants, so if you or someone you know fits the criteria and is interested, it could be a valuable opportunity to improve health during cancer treatment.

Gender

MALE

Eligibility criteria

• Inclusion Criteria:
• • Patients must meet all criteria to be eligible, including travel to Dana-Farber Cancer Institute (DFCI) to collect research data to address the study question.
• • Over 18 years old; children under the age of 18 will be excluded due to the rarity of the disease
• • Histologically diagnosed of localized or metastatic prostate cancer
• • Have been receiving androgen deprivation therapy (ADT) (i.e., luteinizing hormone-releasing hormone \[LHRH\] agonist/antagonist and/or androgen receptor \[AR\] agonist/antagonist) for at least one month with a plan to continue ADT for at least 4 months at the time of recruitment
• • Self-identify as Black
• • Medically cleared to participate in exercise by their referred physician or a certified clinical exercise physiologist
• • Are without medical conditions that could exacerbate with exercise, such as bone disease (excluding bone metastases) at imminent risk of fracture or uncontrolled cardiopulmonary or metabolic diseases
• • Speak English and/or Spanish
• • Currently participate in less than or equal to 60 minutes of moderate or vigorous structured exercise/week
• • Willing to travel to DFCI for necessary data collection
• • Ability to communicate and complete written forms in English and/or Spanish
• Exclusion Criteria:
• • Are not receiving ADT (i.e., LHRH agonist/antagonist and/or AR agonist/antagonist)
• • Pre-existing medical conditions such as uncontrolled cardiopulmonary disease, or metabolic diseases that could exacerbate with exercise
• • Are not English or Spanish speaking
• • Patients with secondary diagnosis (with the exception of basal cell carcinoma)
• • Participate in more than 60 minutes of moderate or vigorous structured exercise/week
• • Unable to travel to DFCI for necessary data collection
• • May not be able to comply with the safety monitoring requirements of the study in the opinion of the investigator.