NRP vs DHOPE vs COR-NMP in ECD-DCD Donation

Launched by ERASMUS MEDICAL CENTER · Apr 11, 2022

Keywords

ClinConnect Summary

This clinical trial is looking at different methods for preserving liver grafts from donors who have died after their heart stopped beating, known as donation after cardiac death (DCD). The goal is to see if a technique called normothermic machine perfusion (NRP) can improve the quality of these livers, making them safer for transplant patients. By simulating the body’s natural blood flow and warming the liver, NRP may help prevent damage to the organ and ensure it is viable for transplantation. The study will also compare NRP with other preservation methods to determine which is most effective.

To participate in the trial, you must be an adult aged 50 to 75 years, and the liver donor must be a DCD donor classified as Maastricht type III or V. Participants will receive a liver graft that has undergone either NRP or other standard methods of preservation. As the trial progresses, researchers will monitor the success of the transplants, any complications, and the overall health of the transplant recipients. This study is important because it aims to increase the availability of suitable livers for transplant, potentially saving more lives.

Gender

ALL

Eligibility criteria

• Inclusion criteria:
• • DCD donor (Maastricht type III and V)
• • Age above 50 years old and below 75 years old
• Exclusion criteria:
• • Malignancy (except for primary non-metastatic central nervous system tumors, non-melanoma skin tumors or cured malignancies)
• • Active infection (sepsis, meningitis, human immune deficiency virus, rubella, rabies, herpes zoster, tuberculosis)
• • Intravenous drug abuse
• • Unknown cause of death
• • In the case of a NRP procedure: donors with a BMI above 35 and transaminases above 1000 U/I and not decreasing prior to donation are excluded