Three-dimensional Analysis of Obliquus Capitis Inferior Muscle Function in the Rotatory Form of Cervical Dystonia

Launched by FONDATION OPHTALMOLOGIQUE ADOLPHE DE ROTHSCHILD · Apr 7, 2022

Keywords

ClinConnect Summary

This clinical trial is investigating the role of a specific neck muscle called the obliquus capitis inferior (OCI) in patients with cervical dystonia, a condition that causes involuntary muscle contractions, leading to abnormal head positions. The trial aims to understand how this muscle behaves in people with cervical dystonia compared to healthy individuals. By using advanced imaging techniques, researchers will look at how the OCI muscle functions before and after treatment with botulinum toxin injections, which are commonly used to help manage this condition.

To participate in this study, individuals must be between 18 and 70 years old and have a confirmed diagnosis of focal cervical dystonia that primarily causes rotational movements. They should also be scheduled to receive botulinum toxin injections targeting the OCI muscle and must give their consent to join the study. Those who cannot sit still during imaging, have other significant neck or neurological conditions, or have had recent treatments affecting the neck may not be eligible. Participants can expect to undergo imaging tests before and five weeks after their treatment, helping researchers learn more about how this muscle contributes to neck movement issues in cervical dystonia.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients between the ages of 18 and 70
• • Presenting with a diagnosed focal CD with predominantly rotational by a neurologist specialized in abnormal movements
• • Receiving botulinum toxin injection at OIC level as part of his treatment
• • Express consent to participate in the study
• • Member of or beneficiary of a social security scheme
• Exclusion Criteria:
• • Mobile DC (scrapie and/or myoclonic) that cannot be controlled the recording time by the CBCT system
• • Having already benefited from an injection of BoNT as part of their DC in the last three months
• • Inability to sit still
• • Neurological condition other than DC (parkinsonian syndrome typical or atypical, others.)
• • Severe neck pain
• • Known or suspected trauma or pathology of the cervical spine, other than DC, having required treatment in the last 6 month
• • Same old surgery of the cervical spine
• • Patient benefiting from a legal protection measure
• • Pregnant or breastfeeding women (a urine pregnancy test will be carried out in women under 50)