Oxalate and Citrate

Launched by UNIVERSITY OF CHICAGO · Apr 11, 2022

Keywords

ClinConnect Summary

This clinical trial, called "Oxalate and Citrate," is studying how two compounds found in food, oxalate and citrate, may influence the formation of kidney stones. The researchers want to understand if these substances can help reduce the chances of developing calcium-based kidney stones. The study is currently looking for participants, including both individuals who have had kidney stones before and those who have never had them.

To be eligible for this trial, participants must be between 18 and 70 years old. Those who have had at least one calcium-based kidney stone can join as "stone formers," while those without a history of kidney stones can participate as "controls." However, participants cannot have certain types of kidney stones or extreme levels of citrate in their urine, and they must be able to stop certain medications during the study. Participants will be contributing to important research that could lead to better prevention strategies for kidney stones, and they will receive guidance throughout the study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• Stone formers:
• • Age 18-70
• • History of at least one calcium-based kidney stone
• Non-stone formers (controls):
• • Age 18-70
• • No history of kidney stone
• • 24-hour urine oxalate within lab normal (\<50mg/day)
• Exclusion Criteria:
• • History of primarily uric acid, cysteine, or struvite stones.
• • History of severe acid-base abnormality, very low (less than 100mg/day) or very high (greater than 1500mg/day) urine citrate.
• • Any controls or stone-forming participants who cannot stop diuretic medication or alkali supplementation for the course of the study period.
• • Non-stone formers and stone-formers with extreme levels of urine citrate will be excluded from this small initial study to reduce heterogeneity and remove focus from the extremes of citrate levels.